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Patterns and risk of HIV-1 transmission network among men who have sex with men in Guangxi, China

The prevalence of HIV-1 in Guangxi is very high, and the rate of HIV-1 infection among men who have sex with men (MSM) has been increasing. Therefore, it is necessary to explore the patterns and risk factors of HIV transmission in Guangxi. For this purpose, individuals diagnosed with HIV-1 during 20...

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Autores principales: Pang, Xianwu, Wei, Hui, Huang, Jinghua, He, Qin, Tang, Kailing, Fang, Ningye, Zhou, Xinjuan, Zhu, Qiuying, Wu, Xiuling, Lan, Guanghua, Shen, Zhiyong, Lin, Mei, Liang, Shujia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7803972/
https://www.ncbi.nlm.nih.gov/pubmed/33436843
http://dx.doi.org/10.1038/s41598-020-79951-2
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author Pang, Xianwu
Wei, Hui
Huang, Jinghua
He, Qin
Tang, Kailing
Fang, Ningye
Zhou, Xinjuan
Zhu, Qiuying
Wu, Xiuling
Lan, Guanghua
Shen, Zhiyong
Lin, Mei
Liang, Shujia
author_facet Pang, Xianwu
Wei, Hui
Huang, Jinghua
He, Qin
Tang, Kailing
Fang, Ningye
Zhou, Xinjuan
Zhu, Qiuying
Wu, Xiuling
Lan, Guanghua
Shen, Zhiyong
Lin, Mei
Liang, Shujia
author_sort Pang, Xianwu
collection PubMed
description The prevalence of HIV-1 in Guangxi is very high, and the rate of HIV-1 infection among men who have sex with men (MSM) has been increasing. Therefore, it is necessary to explore the patterns and risk factors of HIV transmission in Guangxi. For this purpose, individuals diagnosed with HIV-1 during 2013–2018 in Guangxi were recruited. Phylogenetic relationship, transmission clusters, and genotypic drug resistance analyses were performed based on HIV-1 pol sequences. Related factors were analysed to assess for their association with HIV-1 transmission. CRF07_BC (50.4%) and CRF01_AE (33.4%) were found to be the predominant subtypes. The analysed 1633 sequences (50.15%, Guangxi; 49.85%, other provinces) were segregated into 80 clusters (size per cluster, 2–704). We found that 75.3% of the individuals were in three clusters (size ˃ 100), and 73.8% were high-risk spreaders (links ≥ 4). Infection time, marital status, and subtype were significantly associated with HIV-1 transmission. Additionally, 80.2% of recent infections were linked to long-term infections, and 46.2% were linked to other provinces. A low level of transmitted drug resistance was detected (4.8%). Our findings indicated superclusters and high-risk HIV-1 spreaders among the MSM in Guangxi. Effective strategies blocking the route of transmission should be developed.
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spelling pubmed-78039722021-01-13 Patterns and risk of HIV-1 transmission network among men who have sex with men in Guangxi, China Pang, Xianwu Wei, Hui Huang, Jinghua He, Qin Tang, Kailing Fang, Ningye Zhou, Xinjuan Zhu, Qiuying Wu, Xiuling Lan, Guanghua Shen, Zhiyong Lin, Mei Liang, Shujia Sci Rep Article The prevalence of HIV-1 in Guangxi is very high, and the rate of HIV-1 infection among men who have sex with men (MSM) has been increasing. Therefore, it is necessary to explore the patterns and risk factors of HIV transmission in Guangxi. For this purpose, individuals diagnosed with HIV-1 during 2013–2018 in Guangxi were recruited. Phylogenetic relationship, transmission clusters, and genotypic drug resistance analyses were performed based on HIV-1 pol sequences. Related factors were analysed to assess for their association with HIV-1 transmission. CRF07_BC (50.4%) and CRF01_AE (33.4%) were found to be the predominant subtypes. The analysed 1633 sequences (50.15%, Guangxi; 49.85%, other provinces) were segregated into 80 clusters (size per cluster, 2–704). We found that 75.3% of the individuals were in three clusters (size ˃ 100), and 73.8% were high-risk spreaders (links ≥ 4). Infection time, marital status, and subtype were significantly associated with HIV-1 transmission. Additionally, 80.2% of recent infections were linked to long-term infections, and 46.2% were linked to other provinces. A low level of transmitted drug resistance was detected (4.8%). Our findings indicated superclusters and high-risk HIV-1 spreaders among the MSM in Guangxi. Effective strategies blocking the route of transmission should be developed. Nature Publishing Group UK 2021-01-12 /pmc/articles/PMC7803972/ /pubmed/33436843 http://dx.doi.org/10.1038/s41598-020-79951-2 Text en © The Author(s) 2021 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Article
Pang, Xianwu
Wei, Hui
Huang, Jinghua
He, Qin
Tang, Kailing
Fang, Ningye
Zhou, Xinjuan
Zhu, Qiuying
Wu, Xiuling
Lan, Guanghua
Shen, Zhiyong
Lin, Mei
Liang, Shujia
Patterns and risk of HIV-1 transmission network among men who have sex with men in Guangxi, China
title Patterns and risk of HIV-1 transmission network among men who have sex with men in Guangxi, China
title_full Patterns and risk of HIV-1 transmission network among men who have sex with men in Guangxi, China
title_fullStr Patterns and risk of HIV-1 transmission network among men who have sex with men in Guangxi, China
title_full_unstemmed Patterns and risk of HIV-1 transmission network among men who have sex with men in Guangxi, China
title_short Patterns and risk of HIV-1 transmission network among men who have sex with men in Guangxi, China
title_sort patterns and risk of hiv-1 transmission network among men who have sex with men in guangxi, china
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7803972/
https://www.ncbi.nlm.nih.gov/pubmed/33436843
http://dx.doi.org/10.1038/s41598-020-79951-2
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