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Dual EZH2 and G9a inhibition suppresses multiple myeloma cell proliferation by regulating the interferon signal and IRF4-MYC axis

Epigenetic mechanisms such as histone modification play key roles in the pathogenesis of multiple myeloma (MM). We previously showed that EZH2, a histone H3 lysine 27 (H3K27) methyltransferase, and G9, a H3K9 methyltransferase, are potential therapeutic targets in MM. Moreover, recent studies sugges...

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Detalles Bibliográficos
Autores principales:	Ishiguro, Kazuya, Kitajima, Hiroshi, Niinuma, Takeshi, Maruyama, Reo, Nishiyama, Naotaka, Ohtani, Hitoshi, Sudo, Gota, Toyota, Mutsumi, Sasaki, Hajime, Yamamoto, Eiichiro, Kai, Masahiro, Nakase, Hiroshi, Suzuki, Hiromu
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7803977/ https://www.ncbi.nlm.nih.gov/pubmed/33436557 http://dx.doi.org/10.1038/s41420-020-00400-0

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