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Big data and artificial intelligence discover novel drugs targeting proteins without 3D structure and overcome the undruggable targets
The discovery of targeted drugs heavily relies on three-dimensional (3D) structures of target proteins. When the 3D structure of a protein target is unknown, it is very difficult to design its corresponding targeted drugs. Although the 3D structures of some proteins (the so-called undruggable target...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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BMJ Publishing Group
2020
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7804061/ https://www.ncbi.nlm.nih.gov/pubmed/33376199 http://dx.doi.org/10.1136/svn-2019-000323 |