Intracerebral haemorrhage: from clinical settings to animal models

Spontaneous intracerebral haemorrhage (ICH) is a devastating type of stroke with high mortality and morbidity and for which no effective treatments are available to date. Much experimental and clinical research have been performed to explore its mechanisms regard the subsequent inflammatory cascade...

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Autores principales: Bai, Qian, Sheng, Zhaofu, Liu, Yang, Zhang, Ruiyi, Yong, Voon Wee, Xue, Mengzhou
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BMJ Publishing Group 2020
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7804065/
https://www.ncbi.nlm.nih.gov/pubmed/33376200
http://dx.doi.org/10.1136/svn-2020-000334
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author Bai, Qian
Sheng, Zhaofu
Liu, Yang
Zhang, Ruiyi
Yong, Voon Wee
Xue, Mengzhou
author_facet Bai, Qian
Sheng, Zhaofu
Liu, Yang
Zhang, Ruiyi
Yong, Voon Wee
Xue, Mengzhou
author_sort Bai, Qian
collection PubMed
description Spontaneous intracerebral haemorrhage (ICH) is a devastating type of stroke with high mortality and morbidity and for which no effective treatments are available to date. Much experimental and clinical research have been performed to explore its mechanisms regard the subsequent inflammatory cascade and to seek the potential therapeutic strategies. The aim of this review is to discuss insights from clinical settings that have led to the development of numerous animal models of ICH. Some of the current and future challenges for clinicians to understand ICH are also surveyed.
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spelling pubmed-78040652021-01-19 Intracerebral haemorrhage: from clinical settings to animal models Bai, Qian Sheng, Zhaofu Liu, Yang Zhang, Ruiyi Yong, Voon Wee Xue, Mengzhou Stroke Vasc Neurol Review Spontaneous intracerebral haemorrhage (ICH) is a devastating type of stroke with high mortality and morbidity and for which no effective treatments are available to date. Much experimental and clinical research have been performed to explore its mechanisms regard the subsequent inflammatory cascade and to seek the potential therapeutic strategies. The aim of this review is to discuss insights from clinical settings that have led to the development of numerous animal models of ICH. Some of the current and future challenges for clinicians to understand ICH are also surveyed. BMJ Publishing Group 2020-03-26 /pmc/articles/PMC7804065/ /pubmed/33376200 http://dx.doi.org/10.1136/svn-2020-000334 Text en © Author(s) (or their employer(s)) 2020. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ. http://creativecommons.org/licenses/by-nc/4.0/ http://creativecommons.org/licenses/by-nc/4.0/This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/.
spellingShingle Review
Bai, Qian
Sheng, Zhaofu
Liu, Yang
Zhang, Ruiyi
Yong, Voon Wee
Xue, Mengzhou
Intracerebral haemorrhage: from clinical settings to animal models
title Intracerebral haemorrhage: from clinical settings to animal models
title_full Intracerebral haemorrhage: from clinical settings to animal models
title_fullStr Intracerebral haemorrhage: from clinical settings to animal models
title_full_unstemmed Intracerebral haemorrhage: from clinical settings to animal models
title_short Intracerebral haemorrhage: from clinical settings to animal models
title_sort intracerebral haemorrhage: from clinical settings to animal models
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7804065/
https://www.ncbi.nlm.nih.gov/pubmed/33376200
http://dx.doi.org/10.1136/svn-2020-000334
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