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Modelling normal age-related changes in individual retinal layers using location-specific OCT analysis
Current descriptions of retinal thickness across normal age cohorts are mostly limited to global analyses, thus overlooking spatial variation across the retina and limiting spatial analyses of retinal and optic nerve disease. This retrospective cross-sectional study uses location-specific cluster an...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Nature Publishing Group UK
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7804110/ https://www.ncbi.nlm.nih.gov/pubmed/33436715 http://dx.doi.org/10.1038/s41598-020-79424-6 |
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author | Trinh, Matt Khou, Vincent Zangerl, Barbara Kalloniatis, Michael Nivison-Smith, Lisa |
author_facet | Trinh, Matt Khou, Vincent Zangerl, Barbara Kalloniatis, Michael Nivison-Smith, Lisa |
author_sort | Trinh, Matt |
collection | PubMed |
description | Current descriptions of retinal thickness across normal age cohorts are mostly limited to global analyses, thus overlooking spatial variation across the retina and limiting spatial analyses of retinal and optic nerve disease. This retrospective cross-sectional study uses location-specific cluster analysis of 8 × 8 macular average grid-wise thicknesses to quantify topographical patterns and rates of normal, age-related changes in all individual retinal layers of 253 eyes of 253 participants across various age cohorts (n = 23–69 eyes per decade). Most retinal layers had concentric spatial cluster patterns except the retinal nerve fibre layer (RNFL) which displayed a nasal, asymmetric radial pattern. Age-related thickness decline mostly occurred after the late 4th decade, described by quadratic regression models. The ganglion cell layer (GCL), inner plexiform layer (IPL), inner nuclear layer (INL), and outer nuclear layer + Henle’s fibre layer (ONL(+HFL)) were significantly associated with age (p < 0.0001 to < 0.05), demonstrating similar rates of thickness decline (mean pooled slope = − 0.07 µm/year), while the IS/OS had lesser mean pooled thickness slopes for all clusters (− 0.04 µm/year). The RNFL, OPL, and RPE exhibited no significant age-related thickness change, and the RNFL were significantly associated with sex. Analysis using spatial clusters compared to the ETDRS sectors revealed more extensive spatial definition and less variability in the former method. These spatially defined, clustered normative data and age-correction functions provide an accessible method of retinal thickness analysis with more spatial detail and less variability than the ETDRS sectors, potentially aiding the diagnosis and monitoring of retinal and optic nerve disease. |
format | Online Article Text |
id | pubmed-7804110 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-78041102021-01-13 Modelling normal age-related changes in individual retinal layers using location-specific OCT analysis Trinh, Matt Khou, Vincent Zangerl, Barbara Kalloniatis, Michael Nivison-Smith, Lisa Sci Rep Article Current descriptions of retinal thickness across normal age cohorts are mostly limited to global analyses, thus overlooking spatial variation across the retina and limiting spatial analyses of retinal and optic nerve disease. This retrospective cross-sectional study uses location-specific cluster analysis of 8 × 8 macular average grid-wise thicknesses to quantify topographical patterns and rates of normal, age-related changes in all individual retinal layers of 253 eyes of 253 participants across various age cohorts (n = 23–69 eyes per decade). Most retinal layers had concentric spatial cluster patterns except the retinal nerve fibre layer (RNFL) which displayed a nasal, asymmetric radial pattern. Age-related thickness decline mostly occurred after the late 4th decade, described by quadratic regression models. The ganglion cell layer (GCL), inner plexiform layer (IPL), inner nuclear layer (INL), and outer nuclear layer + Henle’s fibre layer (ONL(+HFL)) were significantly associated with age (p < 0.0001 to < 0.05), demonstrating similar rates of thickness decline (mean pooled slope = − 0.07 µm/year), while the IS/OS had lesser mean pooled thickness slopes for all clusters (− 0.04 µm/year). The RNFL, OPL, and RPE exhibited no significant age-related thickness change, and the RNFL were significantly associated with sex. Analysis using spatial clusters compared to the ETDRS sectors revealed more extensive spatial definition and less variability in the former method. These spatially defined, clustered normative data and age-correction functions provide an accessible method of retinal thickness analysis with more spatial detail and less variability than the ETDRS sectors, potentially aiding the diagnosis and monitoring of retinal and optic nerve disease. Nature Publishing Group UK 2021-01-12 /pmc/articles/PMC7804110/ /pubmed/33436715 http://dx.doi.org/10.1038/s41598-020-79424-6 Text en © The Author(s) 2021 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. |
spellingShingle | Article Trinh, Matt Khou, Vincent Zangerl, Barbara Kalloniatis, Michael Nivison-Smith, Lisa Modelling normal age-related changes in individual retinal layers using location-specific OCT analysis |
title | Modelling normal age-related changes in individual retinal layers using location-specific OCT analysis |
title_full | Modelling normal age-related changes in individual retinal layers using location-specific OCT analysis |
title_fullStr | Modelling normal age-related changes in individual retinal layers using location-specific OCT analysis |
title_full_unstemmed | Modelling normal age-related changes in individual retinal layers using location-specific OCT analysis |
title_short | Modelling normal age-related changes in individual retinal layers using location-specific OCT analysis |
title_sort | modelling normal age-related changes in individual retinal layers using location-specific oct analysis |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7804110/ https://www.ncbi.nlm.nih.gov/pubmed/33436715 http://dx.doi.org/10.1038/s41598-020-79424-6 |
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