Targeting adaptor protein SLP76 of RAGE as a therapeutic approach for lethal sepsis

Accumulating evidence shows that RAGE has an important function in the pathogenesis of sepsis. However, the mechanisms by which RAGE transduces signals to downstream kinase cascades during septic shock are not clear. Here, we identify SLP76 as a binding partner for the cytosolic tail of RAGE both in...

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Detalles Bibliográficos
Autores principales: Yan, Zhengzheng, Luo, Haihua, Xie, Bingyao, Tian, Tian, Li, Shan, Chen, Zhixia, Liu, Jinghua, Zhao, Xuwen, Zhang, Liyong, Deng, Yongqiang, Billiar, Timothy R., Jiang, Yong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7804203/
https://www.ncbi.nlm.nih.gov/pubmed/33436632
http://dx.doi.org/10.1038/s41467-020-20577-3

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