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Novel FXR agonist nelumal A suppresses colitis and inflammation-related colorectal carcinogenesis
FXR is a member of the nuclear receptor superfamily and bile acids are endogenous ligands of FXR. FXR activation has recently been reported to inhibit intestinal inflammation and tumour development. This study aimed to investigate whether the novel FXR agonist nelumal A, the active compound of the p...
Autores principales: | Miyazaki, Tsuneyuki, Shirakami, Yohei, Mizutani, Taku, Maruta, Akinori, Ideta, Takayasu, Kubota, Masaya, Sakai, Hiroyasu, Ibuka, Takashi, Genovese, Salvatore, Fiorito, Serena, Taddeo, Vito Alessandro, Epifano, Francesco, Tanaka, Takuji, Shimizu, Masahito |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7804240/ https://www.ncbi.nlm.nih.gov/pubmed/33436792 http://dx.doi.org/10.1038/s41598-020-79916-5 |
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