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Gait parameters of Parkinson’s disease compared with healthy controls: a systematic review and meta-analysis
We systematically reviewed observational and clinical trials (baseline) studies examining differences in gait parameters between Parkinson’s disease (PD) in on-medication state and healthy control. Four electronic databases were searched (November-2018 and updated in October-2020). Independent resea...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7804291/ https://www.ncbi.nlm.nih.gov/pubmed/33436993 http://dx.doi.org/10.1038/s41598-020-80768-2 |
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author | Zanardi, Ana Paula Janner da Silva, Edson Soares Costa, Rochelle Rocha Passos-Monteiro, Elren dos Santos, Ivan Oliveira Kruel, Luiz Fernando Martins Peyré-Tartaruga, Leonardo Alexandre |
author_facet | Zanardi, Ana Paula Janner da Silva, Edson Soares Costa, Rochelle Rocha Passos-Monteiro, Elren dos Santos, Ivan Oliveira Kruel, Luiz Fernando Martins Peyré-Tartaruga, Leonardo Alexandre |
author_sort | Zanardi, Ana Paula Janner |
collection | PubMed |
description | We systematically reviewed observational and clinical trials (baseline) studies examining differences in gait parameters between Parkinson’s disease (PD) in on-medication state and healthy control. Four electronic databases were searched (November-2018 and updated in October-2020). Independent researchers identified studies that evaluated gait parameters measured quantitatively during self-selected walking speed. Risk of bias was assessed using an instrument proposed by Downs and Black (1998). Pooled effects were reported as standardized mean differences and 95% confidence intervals using a random-effects model. A total of 72 studies involving 3027 participants (1510 with PD and 1517 health control) met the inclusion criteria. The self-selected walking speed, stride length, swing time and hip excursion were reduced in people with PD compared with healthy control. Additionally, PD subjects presented higher cadence and double support time. Although with a smaller difference for treadmill, walking speed is reduced both on treadmill (.13 m s(−1)) and on overground (.17 m s(−1)) in PD. The self-select walking speed, stride length, cadence, double support, swing time and sagittal hip angle were altered in people with PD compared with healthy control. The precise determination of these modifications will be beneficial in determining which intervention elements are most critical in bringing about positive, clinically meaningful changes in individuals with PD (PROSPERO protocol CRD42018113042). |
format | Online Article Text |
id | pubmed-7804291 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-78042912021-01-13 Gait parameters of Parkinson’s disease compared with healthy controls: a systematic review and meta-analysis Zanardi, Ana Paula Janner da Silva, Edson Soares Costa, Rochelle Rocha Passos-Monteiro, Elren dos Santos, Ivan Oliveira Kruel, Luiz Fernando Martins Peyré-Tartaruga, Leonardo Alexandre Sci Rep Article We systematically reviewed observational and clinical trials (baseline) studies examining differences in gait parameters between Parkinson’s disease (PD) in on-medication state and healthy control. Four electronic databases were searched (November-2018 and updated in October-2020). Independent researchers identified studies that evaluated gait parameters measured quantitatively during self-selected walking speed. Risk of bias was assessed using an instrument proposed by Downs and Black (1998). Pooled effects were reported as standardized mean differences and 95% confidence intervals using a random-effects model. A total of 72 studies involving 3027 participants (1510 with PD and 1517 health control) met the inclusion criteria. The self-selected walking speed, stride length, swing time and hip excursion were reduced in people with PD compared with healthy control. Additionally, PD subjects presented higher cadence and double support time. Although with a smaller difference for treadmill, walking speed is reduced both on treadmill (.13 m s(−1)) and on overground (.17 m s(−1)) in PD. The self-select walking speed, stride length, cadence, double support, swing time and sagittal hip angle were altered in people with PD compared with healthy control. The precise determination of these modifications will be beneficial in determining which intervention elements are most critical in bringing about positive, clinically meaningful changes in individuals with PD (PROSPERO protocol CRD42018113042). Nature Publishing Group UK 2021-01-12 /pmc/articles/PMC7804291/ /pubmed/33436993 http://dx.doi.org/10.1038/s41598-020-80768-2 Text en © The Author(s) 2021 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. |
spellingShingle | Article Zanardi, Ana Paula Janner da Silva, Edson Soares Costa, Rochelle Rocha Passos-Monteiro, Elren dos Santos, Ivan Oliveira Kruel, Luiz Fernando Martins Peyré-Tartaruga, Leonardo Alexandre Gait parameters of Parkinson’s disease compared with healthy controls: a systematic review and meta-analysis |
title | Gait parameters of Parkinson’s disease compared with healthy controls: a systematic review and meta-analysis |
title_full | Gait parameters of Parkinson’s disease compared with healthy controls: a systematic review and meta-analysis |
title_fullStr | Gait parameters of Parkinson’s disease compared with healthy controls: a systematic review and meta-analysis |
title_full_unstemmed | Gait parameters of Parkinson’s disease compared with healthy controls: a systematic review and meta-analysis |
title_short | Gait parameters of Parkinson’s disease compared with healthy controls: a systematic review and meta-analysis |
title_sort | gait parameters of parkinson’s disease compared with healthy controls: a systematic review and meta-analysis |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7804291/ https://www.ncbi.nlm.nih.gov/pubmed/33436993 http://dx.doi.org/10.1038/s41598-020-80768-2 |
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