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Lysosomal SLC46A3 modulates hepatic cytosolic copper homeostasis

The environmental contaminant 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) causes hepatic toxicity associated with prominent lipid accumulation in humans. Here, the authors report that the lysosomal copper transporter SLC46A3 is induced by TCDD and underlies the hepatic lipid accumulation in mice, pot...

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Detalles Bibliográficos
Autores principales:	Kim, Jung-Hwan, Matsubara, Tsutomu, Lee, Jaekwon, Fenollar-Ferrer, Cristina, Han, Kyungreem, Kim, Donghwan, Jia, Shang, Chang, Christopher J., Yang, Heejung, Nagano, Tomokazu, Krausz, Kristopher W., Yim, Sun-Hee, Gonzalez, Frank J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7804329/ https://www.ncbi.nlm.nih.gov/pubmed/33436590 http://dx.doi.org/10.1038/s41467-020-20461-0

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