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Synthesis, characterization, and imaging of radiopaque bismuth beads for image-guided transarterial embolization
Current therapy for hypervascular cancers, e.g., hepatocellular carcinoma, includes occlusion of the tumor blood supply by arterial infusion of embolic microspheres (beads) suspended in iodine-based contrast under fluoroscopic guidance. Available radiopaque, imageable beads use iodine as the radiopa...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7804415/ https://www.ncbi.nlm.nih.gov/pubmed/33436734 http://dx.doi.org/10.1038/s41598-020-79900-z |
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author | Negussie, Ayele H. de Ruiter, Quirina M. B. Britton, Hugh Donahue, Danielle R. Boffi, Quentin Kim, Young-Seung Pritchard, William F. Moonen, Chrit Storm, Gert Lewis, Andrew L. Wood, Bradford J. |
author_facet | Negussie, Ayele H. de Ruiter, Quirina M. B. Britton, Hugh Donahue, Danielle R. Boffi, Quentin Kim, Young-Seung Pritchard, William F. Moonen, Chrit Storm, Gert Lewis, Andrew L. Wood, Bradford J. |
author_sort | Negussie, Ayele H. |
collection | PubMed |
description | Current therapy for hypervascular cancers, e.g., hepatocellular carcinoma, includes occlusion of the tumor blood supply by arterial infusion of embolic microspheres (beads) suspended in iodine-based contrast under fluoroscopic guidance. Available radiopaque, imageable beads use iodine as the radiopacifier and cannot be differentiated from contrast. This study aimed to synthesize and characterize imageable beads using bismuth as the radiopacifier that could be distinguished from iodine contrast based upon the difference in the binding energy of k-shell electrons (k-edge). Radiodense bismuth beads were successfully synthesized some with uniform bismuth distribution across the beads. The beads were spherical and could be infused through clinical microcatheters. The bismuth beads could be imaged with clinical dual-energy computed tomography (CT), where iodine-based contrast could be distinguished from the microspheres. The ability to separate iodine from bismuth may enhance the diagnostic information acquired on follow-up CT, identifying the distribution of the embolic beads separately from the contrast. Furthermore, with sequential use of iodine- and bismuth-based beads, the two radiopaque beads could be spatially distinguished on imaging, which may enable the development of dual drug delivery and dual tracking. |
format | Online Article Text |
id | pubmed-7804415 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-78044152021-01-13 Synthesis, characterization, and imaging of radiopaque bismuth beads for image-guided transarterial embolization Negussie, Ayele H. de Ruiter, Quirina M. B. Britton, Hugh Donahue, Danielle R. Boffi, Quentin Kim, Young-Seung Pritchard, William F. Moonen, Chrit Storm, Gert Lewis, Andrew L. Wood, Bradford J. Sci Rep Article Current therapy for hypervascular cancers, e.g., hepatocellular carcinoma, includes occlusion of the tumor blood supply by arterial infusion of embolic microspheres (beads) suspended in iodine-based contrast under fluoroscopic guidance. Available radiopaque, imageable beads use iodine as the radiopacifier and cannot be differentiated from contrast. This study aimed to synthesize and characterize imageable beads using bismuth as the radiopacifier that could be distinguished from iodine contrast based upon the difference in the binding energy of k-shell electrons (k-edge). Radiodense bismuth beads were successfully synthesized some with uniform bismuth distribution across the beads. The beads were spherical and could be infused through clinical microcatheters. The bismuth beads could be imaged with clinical dual-energy computed tomography (CT), where iodine-based contrast could be distinguished from the microspheres. The ability to separate iodine from bismuth may enhance the diagnostic information acquired on follow-up CT, identifying the distribution of the embolic beads separately from the contrast. Furthermore, with sequential use of iodine- and bismuth-based beads, the two radiopaque beads could be spatially distinguished on imaging, which may enable the development of dual drug delivery and dual tracking. Nature Publishing Group UK 2021-01-12 /pmc/articles/PMC7804415/ /pubmed/33436734 http://dx.doi.org/10.1038/s41598-020-79900-z Text en © This is a U.S. Government work and not under copyright protection in the US; foreign copyright protection may apply 2021 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . |
spellingShingle | Article Negussie, Ayele H. de Ruiter, Quirina M. B. Britton, Hugh Donahue, Danielle R. Boffi, Quentin Kim, Young-Seung Pritchard, William F. Moonen, Chrit Storm, Gert Lewis, Andrew L. Wood, Bradford J. Synthesis, characterization, and imaging of radiopaque bismuth beads for image-guided transarterial embolization |
title | Synthesis, characterization, and imaging of radiopaque bismuth beads for image-guided transarterial embolization |
title_full | Synthesis, characterization, and imaging of radiopaque bismuth beads for image-guided transarterial embolization |
title_fullStr | Synthesis, characterization, and imaging of radiopaque bismuth beads for image-guided transarterial embolization |
title_full_unstemmed | Synthesis, characterization, and imaging of radiopaque bismuth beads for image-guided transarterial embolization |
title_short | Synthesis, characterization, and imaging of radiopaque bismuth beads for image-guided transarterial embolization |
title_sort | synthesis, characterization, and imaging of radiopaque bismuth beads for image-guided transarterial embolization |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7804415/ https://www.ncbi.nlm.nih.gov/pubmed/33436734 http://dx.doi.org/10.1038/s41598-020-79900-z |
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