Cargando…
The overlap of genetic susceptibility to schizophrenia and cardiometabolic disease can be used to identify metabolically different groups of individuals
Understanding why individuals with severe mental illness (Schizophrenia, Bipolar Disorder and Major Depressive Disorder) have increased risk of cardiometabolic disease (including obesity, type 2 diabetes and cardiovascular disease), and identifying those at highest risk of cardiometabolic disease ar...
Autores principales: | , , , , , , , , , , , , , , , , , , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2021
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7804422/ https://www.ncbi.nlm.nih.gov/pubmed/33436761 http://dx.doi.org/10.1038/s41598-020-79964-x |
_version_ | 1783636160475561984 |
---|---|
author | Strawbridge, Rona J. Johnston, Keira J. A. Bailey, Mark E. S. Baldassarre, Damiano Cullen, Breda Eriksson, Per deFaire, Ulf Ferguson, Amy Gigante, Bruna Giral, Philippe Graham, Nicholas Hamsten, Anders Humphries, Steve E. Kurl, Sudhir Lyall, Donald M. Lyall, Laura M. Pell, Jill P. Pirro, Matteo Savonen, Kai Smit, Andries J. Tremoli, Elena Tomainen, Tomi-Pekka Veglia, Fabrizio Ward, Joey Sennblad, Bengt Smith, Daniel J. |
author_facet | Strawbridge, Rona J. Johnston, Keira J. A. Bailey, Mark E. S. Baldassarre, Damiano Cullen, Breda Eriksson, Per deFaire, Ulf Ferguson, Amy Gigante, Bruna Giral, Philippe Graham, Nicholas Hamsten, Anders Humphries, Steve E. Kurl, Sudhir Lyall, Donald M. Lyall, Laura M. Pell, Jill P. Pirro, Matteo Savonen, Kai Smit, Andries J. Tremoli, Elena Tomainen, Tomi-Pekka Veglia, Fabrizio Ward, Joey Sennblad, Bengt Smith, Daniel J. |
author_sort | Strawbridge, Rona J. |
collection | PubMed |
description | Understanding why individuals with severe mental illness (Schizophrenia, Bipolar Disorder and Major Depressive Disorder) have increased risk of cardiometabolic disease (including obesity, type 2 diabetes and cardiovascular disease), and identifying those at highest risk of cardiometabolic disease are important priority areas for researchers. For individuals with European ancestry we explored whether genetic variation could identify sub-groups with different metabolic profiles. Loci associated with schizophrenia, bipolar disorder and major depressive disorder from previous genome-wide association studies and loci that were also implicated in cardiometabolic processes and diseases were selected. In the IMPROVE study (a high cardiovascular risk sample) and UK Biobank (general population sample) multidimensional scaling was applied to genetic variants implicated in both psychiatric and cardiometabolic disorders. Visual inspection of the resulting plots used to identify distinct clusters. Differences between these clusters were assessed using chi-squared and Kruskall-Wallis tests. In IMPROVE, genetic loci associated with both schizophrenia and cardiometabolic disease (but not bipolar disorder or major depressive disorder) identified three groups of individuals with distinct metabolic profiles. This grouping was replicated within UK Biobank, with somewhat less distinction between metabolic profiles. This work focused on individuals of European ancestry and is unlikely to apply to more genetically diverse populations. Overall, this study provides proof of concept that common biology underlying mental and physical illness may help to stratify subsets of individuals with different cardiometabolic profiles. |
format | Online Article Text |
id | pubmed-7804422 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-78044222021-01-13 The overlap of genetic susceptibility to schizophrenia and cardiometabolic disease can be used to identify metabolically different groups of individuals Strawbridge, Rona J. Johnston, Keira J. A. Bailey, Mark E. S. Baldassarre, Damiano Cullen, Breda Eriksson, Per deFaire, Ulf Ferguson, Amy Gigante, Bruna Giral, Philippe Graham, Nicholas Hamsten, Anders Humphries, Steve E. Kurl, Sudhir Lyall, Donald M. Lyall, Laura M. Pell, Jill P. Pirro, Matteo Savonen, Kai Smit, Andries J. Tremoli, Elena Tomainen, Tomi-Pekka Veglia, Fabrizio Ward, Joey Sennblad, Bengt Smith, Daniel J. Sci Rep Article Understanding why individuals with severe mental illness (Schizophrenia, Bipolar Disorder and Major Depressive Disorder) have increased risk of cardiometabolic disease (including obesity, type 2 diabetes and cardiovascular disease), and identifying those at highest risk of cardiometabolic disease are important priority areas for researchers. For individuals with European ancestry we explored whether genetic variation could identify sub-groups with different metabolic profiles. Loci associated with schizophrenia, bipolar disorder and major depressive disorder from previous genome-wide association studies and loci that were also implicated in cardiometabolic processes and diseases were selected. In the IMPROVE study (a high cardiovascular risk sample) and UK Biobank (general population sample) multidimensional scaling was applied to genetic variants implicated in both psychiatric and cardiometabolic disorders. Visual inspection of the resulting plots used to identify distinct clusters. Differences between these clusters were assessed using chi-squared and Kruskall-Wallis tests. In IMPROVE, genetic loci associated with both schizophrenia and cardiometabolic disease (but not bipolar disorder or major depressive disorder) identified three groups of individuals with distinct metabolic profiles. This grouping was replicated within UK Biobank, with somewhat less distinction between metabolic profiles. This work focused on individuals of European ancestry and is unlikely to apply to more genetically diverse populations. Overall, this study provides proof of concept that common biology underlying mental and physical illness may help to stratify subsets of individuals with different cardiometabolic profiles. Nature Publishing Group UK 2021-01-12 /pmc/articles/PMC7804422/ /pubmed/33436761 http://dx.doi.org/10.1038/s41598-020-79964-x Text en © The Author(s) 2021 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. |
spellingShingle | Article Strawbridge, Rona J. Johnston, Keira J. A. Bailey, Mark E. S. Baldassarre, Damiano Cullen, Breda Eriksson, Per deFaire, Ulf Ferguson, Amy Gigante, Bruna Giral, Philippe Graham, Nicholas Hamsten, Anders Humphries, Steve E. Kurl, Sudhir Lyall, Donald M. Lyall, Laura M. Pell, Jill P. Pirro, Matteo Savonen, Kai Smit, Andries J. Tremoli, Elena Tomainen, Tomi-Pekka Veglia, Fabrizio Ward, Joey Sennblad, Bengt Smith, Daniel J. The overlap of genetic susceptibility to schizophrenia and cardiometabolic disease can be used to identify metabolically different groups of individuals |
title | The overlap of genetic susceptibility to schizophrenia and cardiometabolic disease can be used to identify metabolically different groups of individuals |
title_full | The overlap of genetic susceptibility to schizophrenia and cardiometabolic disease can be used to identify metabolically different groups of individuals |
title_fullStr | The overlap of genetic susceptibility to schizophrenia and cardiometabolic disease can be used to identify metabolically different groups of individuals |
title_full_unstemmed | The overlap of genetic susceptibility to schizophrenia and cardiometabolic disease can be used to identify metabolically different groups of individuals |
title_short | The overlap of genetic susceptibility to schizophrenia and cardiometabolic disease can be used to identify metabolically different groups of individuals |
title_sort | overlap of genetic susceptibility to schizophrenia and cardiometabolic disease can be used to identify metabolically different groups of individuals |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7804422/ https://www.ncbi.nlm.nih.gov/pubmed/33436761 http://dx.doi.org/10.1038/s41598-020-79964-x |
work_keys_str_mv | AT strawbridgeronaj theoverlapofgeneticsusceptibilitytoschizophreniaandcardiometabolicdiseasecanbeusedtoidentifymetabolicallydifferentgroupsofindividuals AT johnstonkeiraja theoverlapofgeneticsusceptibilitytoschizophreniaandcardiometabolicdiseasecanbeusedtoidentifymetabolicallydifferentgroupsofindividuals AT baileymarkes theoverlapofgeneticsusceptibilitytoschizophreniaandcardiometabolicdiseasecanbeusedtoidentifymetabolicallydifferentgroupsofindividuals AT baldassarredamiano theoverlapofgeneticsusceptibilitytoschizophreniaandcardiometabolicdiseasecanbeusedtoidentifymetabolicallydifferentgroupsofindividuals AT cullenbreda theoverlapofgeneticsusceptibilitytoschizophreniaandcardiometabolicdiseasecanbeusedtoidentifymetabolicallydifferentgroupsofindividuals AT erikssonper theoverlapofgeneticsusceptibilitytoschizophreniaandcardiometabolicdiseasecanbeusedtoidentifymetabolicallydifferentgroupsofindividuals AT defaireulf theoverlapofgeneticsusceptibilitytoschizophreniaandcardiometabolicdiseasecanbeusedtoidentifymetabolicallydifferentgroupsofindividuals AT fergusonamy theoverlapofgeneticsusceptibilitytoschizophreniaandcardiometabolicdiseasecanbeusedtoidentifymetabolicallydifferentgroupsofindividuals AT gigantebruna theoverlapofgeneticsusceptibilitytoschizophreniaandcardiometabolicdiseasecanbeusedtoidentifymetabolicallydifferentgroupsofindividuals AT giralphilippe theoverlapofgeneticsusceptibilitytoschizophreniaandcardiometabolicdiseasecanbeusedtoidentifymetabolicallydifferentgroupsofindividuals AT grahamnicholas theoverlapofgeneticsusceptibilitytoschizophreniaandcardiometabolicdiseasecanbeusedtoidentifymetabolicallydifferentgroupsofindividuals AT hamstenanders theoverlapofgeneticsusceptibilitytoschizophreniaandcardiometabolicdiseasecanbeusedtoidentifymetabolicallydifferentgroupsofindividuals AT humphriesstevee theoverlapofgeneticsusceptibilitytoschizophreniaandcardiometabolicdiseasecanbeusedtoidentifymetabolicallydifferentgroupsofindividuals AT kurlsudhir theoverlapofgeneticsusceptibilitytoschizophreniaandcardiometabolicdiseasecanbeusedtoidentifymetabolicallydifferentgroupsofindividuals AT lyalldonaldm theoverlapofgeneticsusceptibilitytoschizophreniaandcardiometabolicdiseasecanbeusedtoidentifymetabolicallydifferentgroupsofindividuals AT lyalllauram theoverlapofgeneticsusceptibilitytoschizophreniaandcardiometabolicdiseasecanbeusedtoidentifymetabolicallydifferentgroupsofindividuals AT pelljillp theoverlapofgeneticsusceptibilitytoschizophreniaandcardiometabolicdiseasecanbeusedtoidentifymetabolicallydifferentgroupsofindividuals AT pirromatteo theoverlapofgeneticsusceptibilitytoschizophreniaandcardiometabolicdiseasecanbeusedtoidentifymetabolicallydifferentgroupsofindividuals AT savonenkai theoverlapofgeneticsusceptibilitytoschizophreniaandcardiometabolicdiseasecanbeusedtoidentifymetabolicallydifferentgroupsofindividuals AT smitandriesj theoverlapofgeneticsusceptibilitytoschizophreniaandcardiometabolicdiseasecanbeusedtoidentifymetabolicallydifferentgroupsofindividuals AT tremolielena theoverlapofgeneticsusceptibilitytoschizophreniaandcardiometabolicdiseasecanbeusedtoidentifymetabolicallydifferentgroupsofindividuals AT tomainentomipekka theoverlapofgeneticsusceptibilitytoschizophreniaandcardiometabolicdiseasecanbeusedtoidentifymetabolicallydifferentgroupsofindividuals AT vegliafabrizio theoverlapofgeneticsusceptibilitytoschizophreniaandcardiometabolicdiseasecanbeusedtoidentifymetabolicallydifferentgroupsofindividuals AT wardjoey theoverlapofgeneticsusceptibilitytoschizophreniaandcardiometabolicdiseasecanbeusedtoidentifymetabolicallydifferentgroupsofindividuals AT sennbladbengt theoverlapofgeneticsusceptibilitytoschizophreniaandcardiometabolicdiseasecanbeusedtoidentifymetabolicallydifferentgroupsofindividuals AT smithdanielj theoverlapofgeneticsusceptibilitytoschizophreniaandcardiometabolicdiseasecanbeusedtoidentifymetabolicallydifferentgroupsofindividuals AT strawbridgeronaj overlapofgeneticsusceptibilitytoschizophreniaandcardiometabolicdiseasecanbeusedtoidentifymetabolicallydifferentgroupsofindividuals AT johnstonkeiraja overlapofgeneticsusceptibilitytoschizophreniaandcardiometabolicdiseasecanbeusedtoidentifymetabolicallydifferentgroupsofindividuals AT baileymarkes overlapofgeneticsusceptibilitytoschizophreniaandcardiometabolicdiseasecanbeusedtoidentifymetabolicallydifferentgroupsofindividuals AT baldassarredamiano overlapofgeneticsusceptibilitytoschizophreniaandcardiometabolicdiseasecanbeusedtoidentifymetabolicallydifferentgroupsofindividuals AT cullenbreda overlapofgeneticsusceptibilitytoschizophreniaandcardiometabolicdiseasecanbeusedtoidentifymetabolicallydifferentgroupsofindividuals AT erikssonper overlapofgeneticsusceptibilitytoschizophreniaandcardiometabolicdiseasecanbeusedtoidentifymetabolicallydifferentgroupsofindividuals AT defaireulf overlapofgeneticsusceptibilitytoschizophreniaandcardiometabolicdiseasecanbeusedtoidentifymetabolicallydifferentgroupsofindividuals AT fergusonamy overlapofgeneticsusceptibilitytoschizophreniaandcardiometabolicdiseasecanbeusedtoidentifymetabolicallydifferentgroupsofindividuals AT gigantebruna overlapofgeneticsusceptibilitytoschizophreniaandcardiometabolicdiseasecanbeusedtoidentifymetabolicallydifferentgroupsofindividuals AT giralphilippe overlapofgeneticsusceptibilitytoschizophreniaandcardiometabolicdiseasecanbeusedtoidentifymetabolicallydifferentgroupsofindividuals AT grahamnicholas overlapofgeneticsusceptibilitytoschizophreniaandcardiometabolicdiseasecanbeusedtoidentifymetabolicallydifferentgroupsofindividuals AT hamstenanders overlapofgeneticsusceptibilitytoschizophreniaandcardiometabolicdiseasecanbeusedtoidentifymetabolicallydifferentgroupsofindividuals AT humphriesstevee overlapofgeneticsusceptibilitytoschizophreniaandcardiometabolicdiseasecanbeusedtoidentifymetabolicallydifferentgroupsofindividuals AT kurlsudhir overlapofgeneticsusceptibilitytoschizophreniaandcardiometabolicdiseasecanbeusedtoidentifymetabolicallydifferentgroupsofindividuals AT lyalldonaldm overlapofgeneticsusceptibilitytoschizophreniaandcardiometabolicdiseasecanbeusedtoidentifymetabolicallydifferentgroupsofindividuals AT lyalllauram overlapofgeneticsusceptibilitytoschizophreniaandcardiometabolicdiseasecanbeusedtoidentifymetabolicallydifferentgroupsofindividuals AT pelljillp overlapofgeneticsusceptibilitytoschizophreniaandcardiometabolicdiseasecanbeusedtoidentifymetabolicallydifferentgroupsofindividuals AT pirromatteo overlapofgeneticsusceptibilitytoschizophreniaandcardiometabolicdiseasecanbeusedtoidentifymetabolicallydifferentgroupsofindividuals AT savonenkai overlapofgeneticsusceptibilitytoschizophreniaandcardiometabolicdiseasecanbeusedtoidentifymetabolicallydifferentgroupsofindividuals AT smitandriesj overlapofgeneticsusceptibilitytoschizophreniaandcardiometabolicdiseasecanbeusedtoidentifymetabolicallydifferentgroupsofindividuals AT tremolielena overlapofgeneticsusceptibilitytoschizophreniaandcardiometabolicdiseasecanbeusedtoidentifymetabolicallydifferentgroupsofindividuals AT tomainentomipekka overlapofgeneticsusceptibilitytoschizophreniaandcardiometabolicdiseasecanbeusedtoidentifymetabolicallydifferentgroupsofindividuals AT vegliafabrizio overlapofgeneticsusceptibilitytoschizophreniaandcardiometabolicdiseasecanbeusedtoidentifymetabolicallydifferentgroupsofindividuals AT wardjoey overlapofgeneticsusceptibilitytoschizophreniaandcardiometabolicdiseasecanbeusedtoidentifymetabolicallydifferentgroupsofindividuals AT sennbladbengt overlapofgeneticsusceptibilitytoschizophreniaandcardiometabolicdiseasecanbeusedtoidentifymetabolicallydifferentgroupsofindividuals AT smithdanielj overlapofgeneticsusceptibilitytoschizophreniaandcardiometabolicdiseasecanbeusedtoidentifymetabolicallydifferentgroupsofindividuals |