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Increased levels of pentraxins protein and cytokines bear good association in patients with severe dengue infection

Dengue is an arboviral infection with high rates of morbidity and mortality throughout the tropics and sub-tropics. This work studied the status of pentraxin (CRP/SAP) protein, ferritin, TNF-α and IL-1β levels in Dengue patients of different pathophysiological manifestations. Accordingly, clinically...

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Autores principales: Patra, Goutam, Saha, Bibhuti, Mukhopadhyay, Sumi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7804429/
https://www.ncbi.nlm.nih.gov/pubmed/33436908
http://dx.doi.org/10.1038/s41598-020-80144-0
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author Patra, Goutam
Saha, Bibhuti
Mukhopadhyay, Sumi
author_facet Patra, Goutam
Saha, Bibhuti
Mukhopadhyay, Sumi
author_sort Patra, Goutam
collection PubMed
description Dengue is an arboviral infection with high rates of morbidity and mortality throughout the tropics and sub-tropics. This work studied the status of pentraxin (CRP/SAP) protein, ferritin, TNF-α and IL-1β levels in Dengue patients of different pathophysiological manifestations. Accordingly, clinically confirmed Dengue cases (n = 97) were enrolled and subsequently blood parameters were studied by Haematology cell counter and Biochemistry Autoanalyser. CRP, SAP, ferritin, TNF-α and IL-1β ELISA were done in all the samples by using standard ELISA kits. Statistical Analysis was done in all the experiments. The levels of CRP (p < 0.0001), SAP (p < 0.0001), ferritin (p < 0.0001), TNF-α (p < 0.0001) and IL-1β (p < 0.0001) were high in patients with Severe Dengue as compared to Dengue without warning signs. High levels of SGOT, SGPT and decreased platelet counts were found in severe patients as compared to Healthy donor. CRP/SAP as well as TNF-α/IL-1β were independently associated with both dengue severity and overall disease manifestation. Statistically significant increased CRP, SAP, ferritin, TNF-α and IL-1β titres were correlated in patients with severe clinical manifestations as compared to mild disease forms of dengue. Elevated levels of pentraxin, TNF-α/IL-1β in blood during dengue infection could act as an early predictor in Severe Dengue infection.
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spelling pubmed-78044292021-01-13 Increased levels of pentraxins protein and cytokines bear good association in patients with severe dengue infection Patra, Goutam Saha, Bibhuti Mukhopadhyay, Sumi Sci Rep Article Dengue is an arboviral infection with high rates of morbidity and mortality throughout the tropics and sub-tropics. This work studied the status of pentraxin (CRP/SAP) protein, ferritin, TNF-α and IL-1β levels in Dengue patients of different pathophysiological manifestations. Accordingly, clinically confirmed Dengue cases (n = 97) were enrolled and subsequently blood parameters were studied by Haematology cell counter and Biochemistry Autoanalyser. CRP, SAP, ferritin, TNF-α and IL-1β ELISA were done in all the samples by using standard ELISA kits. Statistical Analysis was done in all the experiments. The levels of CRP (p < 0.0001), SAP (p < 0.0001), ferritin (p < 0.0001), TNF-α (p < 0.0001) and IL-1β (p < 0.0001) were high in patients with Severe Dengue as compared to Dengue without warning signs. High levels of SGOT, SGPT and decreased platelet counts were found in severe patients as compared to Healthy donor. CRP/SAP as well as TNF-α/IL-1β were independently associated with both dengue severity and overall disease manifestation. Statistically significant increased CRP, SAP, ferritin, TNF-α and IL-1β titres were correlated in patients with severe clinical manifestations as compared to mild disease forms of dengue. Elevated levels of pentraxin, TNF-α/IL-1β in blood during dengue infection could act as an early predictor in Severe Dengue infection. Nature Publishing Group UK 2021-01-12 /pmc/articles/PMC7804429/ /pubmed/33436908 http://dx.doi.org/10.1038/s41598-020-80144-0 Text en © The Author(s) 2021 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Article
Patra, Goutam
Saha, Bibhuti
Mukhopadhyay, Sumi
Increased levels of pentraxins protein and cytokines bear good association in patients with severe dengue infection
title Increased levels of pentraxins protein and cytokines bear good association in patients with severe dengue infection
title_full Increased levels of pentraxins protein and cytokines bear good association in patients with severe dengue infection
title_fullStr Increased levels of pentraxins protein and cytokines bear good association in patients with severe dengue infection
title_full_unstemmed Increased levels of pentraxins protein and cytokines bear good association in patients with severe dengue infection
title_short Increased levels of pentraxins protein and cytokines bear good association in patients with severe dengue infection
title_sort increased levels of pentraxins protein and cytokines bear good association in patients with severe dengue infection
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7804429/
https://www.ncbi.nlm.nih.gov/pubmed/33436908
http://dx.doi.org/10.1038/s41598-020-80144-0
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