Synthesis and tumour cell uptake studies of gadolinium(III)–phosphonium complexes

The synthesis of a new series of Gd(III)-arylphosphonium complexes is described and the solution stability of selected compounds is reported. Their lipophilicity and uptake in human glial (SVG p12) and human glioblastoma multiforme (T98G) cell lines are presented. The in vitro cytotoxicity of all co...

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Autores principales: Hall, Andrew J., Robertson, Amy G., Hill, Leila R., Rendina, Louis M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7804430/
https://www.ncbi.nlm.nih.gov/pubmed/33436690
http://dx.doi.org/10.1038/s41598-020-79893-9
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author Hall, Andrew J.
Robertson, Amy G.
Hill, Leila R.
Rendina, Louis M.
author_facet Hall, Andrew J.
Robertson, Amy G.
Hill, Leila R.
Rendina, Louis M.
author_sort Hall, Andrew J.
collection PubMed
description The synthesis of a new series of Gd(III)-arylphosphonium complexes is described and the solution stability of selected compounds is reported. Their lipophilicity and uptake in human glial (SVG p12) and human glioblastoma multiforme (T98G) cell lines are presented. The in vitro cytotoxicity of all complexes was determined to be low at therapeutically-relevant concentrations. Selected Gd(III) complexes are potential candidates for further investigation as theranostic agents.
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spelling pubmed-78044302021-01-13 Synthesis and tumour cell uptake studies of gadolinium(III)–phosphonium complexes Hall, Andrew J. Robertson, Amy G. Hill, Leila R. Rendina, Louis M. Sci Rep Article The synthesis of a new series of Gd(III)-arylphosphonium complexes is described and the solution stability of selected compounds is reported. Their lipophilicity and uptake in human glial (SVG p12) and human glioblastoma multiforme (T98G) cell lines are presented. The in vitro cytotoxicity of all complexes was determined to be low at therapeutically-relevant concentrations. Selected Gd(III) complexes are potential candidates for further investigation as theranostic agents. Nature Publishing Group UK 2021-01-12 /pmc/articles/PMC7804430/ /pubmed/33436690 http://dx.doi.org/10.1038/s41598-020-79893-9 Text en © The Author(s) 2021 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Article
Hall, Andrew J.
Robertson, Amy G.
Hill, Leila R.
Rendina, Louis M.
Synthesis and tumour cell uptake studies of gadolinium(III)–phosphonium complexes
title Synthesis and tumour cell uptake studies of gadolinium(III)–phosphonium complexes
title_full Synthesis and tumour cell uptake studies of gadolinium(III)–phosphonium complexes
title_fullStr Synthesis and tumour cell uptake studies of gadolinium(III)–phosphonium complexes
title_full_unstemmed Synthesis and tumour cell uptake studies of gadolinium(III)–phosphonium complexes
title_short Synthesis and tumour cell uptake studies of gadolinium(III)–phosphonium complexes
title_sort synthesis and tumour cell uptake studies of gadolinium(iii)–phosphonium complexes
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7804430/
https://www.ncbi.nlm.nih.gov/pubmed/33436690
http://dx.doi.org/10.1038/s41598-020-79893-9
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