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Structural insights into TSC complex assembly and GAP activity on Rheb

Tuberous sclerosis complex (TSC) integrates upstream stimuli and regulates cell growth by controlling the activity of mTORC1. TSC complex functions as a GTPase-activating protein (GAP) towards small GTPase Rheb and inhibits Rheb-mediated activation of mTORC1. Mutations in TSC genes cause tuberous sc...

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Detalles Bibliográficos
Autores principales:	Yang, Huirong, Yu, Zishuo, Chen, Xizi, Li, Jiabei, Li, Ningning, Cheng, Jiaxuan, Gao, Ning, Yuan, Hai-Xin, Ye, Dan, Guan, Kun-Liang, Xu, Yanhui
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7804450/ https://www.ncbi.nlm.nih.gov/pubmed/33436626 http://dx.doi.org/10.1038/s41467-020-20522-4

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