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Novel CFD modeling approaches to assessing urine flow in prostatic urethra after transurethral surgery

Assessment of the pressure and velocity of urine flow for different diameter ratios of prostatic urethra (RPU) after transurethral surgery using computational fluid dynamics (CFD). A standardized and idealized two-dimensional CFD model after transurethral surgery (CATS-1st) was developed for post-su...

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Autores principales: Zhang, Bin, Liu, Shuang, Liu, Yinxia, Wu, Bo, Zhang, Xuhui, Wang, Xin, Liang, Xuezhi, Cao, Xiaoming, Wang, Dongwen, Wu, Chin-Lee
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7804846/
https://www.ncbi.nlm.nih.gov/pubmed/33436678
http://dx.doi.org/10.1038/s41598-020-79505-6
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author Zhang, Bin
Liu, Shuang
Liu, Yinxia
Wu, Bo
Zhang, Xuhui
Wang, Xin
Liang, Xuezhi
Cao, Xiaoming
Wang, Dongwen
Wu, Chin-Lee
author_facet Zhang, Bin
Liu, Shuang
Liu, Yinxia
Wu, Bo
Zhang, Xuhui
Wang, Xin
Liang, Xuezhi
Cao, Xiaoming
Wang, Dongwen
Wu, Chin-Lee
author_sort Zhang, Bin
collection PubMed
description Assessment of the pressure and velocity of urine flow for different diameter ratios of prostatic urethra (RPU) after transurethral surgery using computational fluid dynamics (CFD). A standardized and idealized two-dimensional CFD model after transurethral surgery (CATS-1st) was developed for post-surgery mid-voiding. Using CATS-1st, 210 examples were amplified according to an array of size [3][5][14], which contained three groups of longitudinal diameters of prostatic urethra (LD-PU). Each of these groups contained five subgroups of transverse diameters of the bladder neck (TD-BN), each with 14 examples of transverse diameters of PU (TD-PU). The pressure and velocity of urine flow were monitored through flow dynamics simulation, and the relationship among RPU-1 (TD-PU/TD-BN), RPU-2 (RPU-1/LD-PU), the transverse diameter of the vortex, and the midpoint velocity of the external urethral orifice (MV-EUO) was determined. A total of 210 CATS examples, including CATS-1st examples, were analyzed. High (bladder and PU) and medium/low (the rest of the urethra) pressure zones, and low (bladder), medium (PU), and high (the rest of the urethra) velocity zones were determined. The rapid changes in the velocity were concentrated in and around the PU. Laminar flow was present in all the examples. The vortices appeared and then gradually shrank with reducing RPU on both the sides of PU in 182 examples. In the vortex examples, minimum RPU-1 and RPU-2 reached close to the values of 0.79 and 0.02, respectively. MV-EUO increased gradually with decreasing RPU. In comparison to the vortex examples, the non-vortex examples exhibited a significantly higher (p < 0.01) MV-EUO. The developed CFD models (CATS) presented an effective simulation of urine flow behavior within the PU after transurethral surgery for benign prostatic hyperplasia (BPH). These models could prove to be useful for morphological repair in PU after transurethral surgery.
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spelling pubmed-78048462021-01-13 Novel CFD modeling approaches to assessing urine flow in prostatic urethra after transurethral surgery Zhang, Bin Liu, Shuang Liu, Yinxia Wu, Bo Zhang, Xuhui Wang, Xin Liang, Xuezhi Cao, Xiaoming Wang, Dongwen Wu, Chin-Lee Sci Rep Article Assessment of the pressure and velocity of urine flow for different diameter ratios of prostatic urethra (RPU) after transurethral surgery using computational fluid dynamics (CFD). A standardized and idealized two-dimensional CFD model after transurethral surgery (CATS-1st) was developed for post-surgery mid-voiding. Using CATS-1st, 210 examples were amplified according to an array of size [3][5][14], which contained three groups of longitudinal diameters of prostatic urethra (LD-PU). Each of these groups contained five subgroups of transverse diameters of the bladder neck (TD-BN), each with 14 examples of transverse diameters of PU (TD-PU). The pressure and velocity of urine flow were monitored through flow dynamics simulation, and the relationship among RPU-1 (TD-PU/TD-BN), RPU-2 (RPU-1/LD-PU), the transverse diameter of the vortex, and the midpoint velocity of the external urethral orifice (MV-EUO) was determined. A total of 210 CATS examples, including CATS-1st examples, were analyzed. High (bladder and PU) and medium/low (the rest of the urethra) pressure zones, and low (bladder), medium (PU), and high (the rest of the urethra) velocity zones were determined. The rapid changes in the velocity were concentrated in and around the PU. Laminar flow was present in all the examples. The vortices appeared and then gradually shrank with reducing RPU on both the sides of PU in 182 examples. In the vortex examples, minimum RPU-1 and RPU-2 reached close to the values of 0.79 and 0.02, respectively. MV-EUO increased gradually with decreasing RPU. In comparison to the vortex examples, the non-vortex examples exhibited a significantly higher (p < 0.01) MV-EUO. The developed CFD models (CATS) presented an effective simulation of urine flow behavior within the PU after transurethral surgery for benign prostatic hyperplasia (BPH). These models could prove to be useful for morphological repair in PU after transurethral surgery. Nature Publishing Group UK 2021-01-12 /pmc/articles/PMC7804846/ /pubmed/33436678 http://dx.doi.org/10.1038/s41598-020-79505-6 Text en © The Author(s) 2021 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Article
Zhang, Bin
Liu, Shuang
Liu, Yinxia
Wu, Bo
Zhang, Xuhui
Wang, Xin
Liang, Xuezhi
Cao, Xiaoming
Wang, Dongwen
Wu, Chin-Lee
Novel CFD modeling approaches to assessing urine flow in prostatic urethra after transurethral surgery
title Novel CFD modeling approaches to assessing urine flow in prostatic urethra after transurethral surgery
title_full Novel CFD modeling approaches to assessing urine flow in prostatic urethra after transurethral surgery
title_fullStr Novel CFD modeling approaches to assessing urine flow in prostatic urethra after transurethral surgery
title_full_unstemmed Novel CFD modeling approaches to assessing urine flow in prostatic urethra after transurethral surgery
title_short Novel CFD modeling approaches to assessing urine flow in prostatic urethra after transurethral surgery
title_sort novel cfd modeling approaches to assessing urine flow in prostatic urethra after transurethral surgery
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7804846/
https://www.ncbi.nlm.nih.gov/pubmed/33436678
http://dx.doi.org/10.1038/s41598-020-79505-6
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