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Neurovascular Unit: A critical role in ischemic stroke
Ischemic stroke (IS), a common cerebrovascular disease, results from a sudden blockage of a blood vessel in the brain, thereby restricting blood supply to the area in question, and making a significantly negative impact on human health. Unfortunately, current treatments, that are mainly based on a r...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7804897/ https://www.ncbi.nlm.nih.gov/pubmed/33389780 http://dx.doi.org/10.1111/cns.13561 |
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author | Wang, Liyun Xiong, Xiaoxing Zhang, Luyuan Shen, Jian |
author_facet | Wang, Liyun Xiong, Xiaoxing Zhang, Luyuan Shen, Jian |
author_sort | Wang, Liyun |
collection | PubMed |
description | Ischemic stroke (IS), a common cerebrovascular disease, results from a sudden blockage of a blood vessel in the brain, thereby restricting blood supply to the area in question, and making a significantly negative impact on human health. Unfortunately, current treatments, that are mainly based on a recanalization of occluded blood vessels, are insufficient or inaccessible to many stroke patients. Recently, the profound influence of the neurovascular unit (NVU) on recanalization and the prognosis of IS have become better understood; in‐depth studies of the NVU have also provided novel approaches for IS treatment. In this article, we review the intimate connections between the changes in the NVU and IS outcomes, and discuss possible new management strategies having practical significance to IS. We discuss the concept of the NVU, as well as its roles in IS blood‐brain barrier regulation, cell preservation, inflammatory immune response, and neurovascular repair. Besides, we also summarize the influence of noncoding RNAs in NVU, and IS therapies targeting the NVU. We conclude that both the pathophysiological and neurovascular repair processes of IS are strongly associated with the homeostatic state of the NVU and that further research into therapies directed at the NVU could expand the range of treatments available for IS. |
format | Online Article Text |
id | pubmed-7804897 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | John Wiley and Sons Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-78048972021-01-29 Neurovascular Unit: A critical role in ischemic stroke Wang, Liyun Xiong, Xiaoxing Zhang, Luyuan Shen, Jian CNS Neurosci Ther Review Articles Ischemic stroke (IS), a common cerebrovascular disease, results from a sudden blockage of a blood vessel in the brain, thereby restricting blood supply to the area in question, and making a significantly negative impact on human health. Unfortunately, current treatments, that are mainly based on a recanalization of occluded blood vessels, are insufficient or inaccessible to many stroke patients. Recently, the profound influence of the neurovascular unit (NVU) on recanalization and the prognosis of IS have become better understood; in‐depth studies of the NVU have also provided novel approaches for IS treatment. In this article, we review the intimate connections between the changes in the NVU and IS outcomes, and discuss possible new management strategies having practical significance to IS. We discuss the concept of the NVU, as well as its roles in IS blood‐brain barrier regulation, cell preservation, inflammatory immune response, and neurovascular repair. Besides, we also summarize the influence of noncoding RNAs in NVU, and IS therapies targeting the NVU. We conclude that both the pathophysiological and neurovascular repair processes of IS are strongly associated with the homeostatic state of the NVU and that further research into therapies directed at the NVU could expand the range of treatments available for IS. John Wiley and Sons Inc. 2021-01-02 /pmc/articles/PMC7804897/ /pubmed/33389780 http://dx.doi.org/10.1111/cns.13561 Text en © 2021 The Authors. CNS Neuroscience & Therapeutics Published by John Wiley & Sons Ltd. This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Articles Wang, Liyun Xiong, Xiaoxing Zhang, Luyuan Shen, Jian Neurovascular Unit: A critical role in ischemic stroke |
title | Neurovascular Unit: A critical role in ischemic stroke |
title_full | Neurovascular Unit: A critical role in ischemic stroke |
title_fullStr | Neurovascular Unit: A critical role in ischemic stroke |
title_full_unstemmed | Neurovascular Unit: A critical role in ischemic stroke |
title_short | Neurovascular Unit: A critical role in ischemic stroke |
title_sort | neurovascular unit: a critical role in ischemic stroke |
topic | Review Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7804897/ https://www.ncbi.nlm.nih.gov/pubmed/33389780 http://dx.doi.org/10.1111/cns.13561 |
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