Interplay between chromosomal alterations and gene mutations shapes the evolutionary trajectory of clonal hematopoiesis

Stably acquired mutations in hematopoietic cells represent substrates of selection that may lead to clonal hematopoiesis (CH), a common state in cancer patients that is associated with a heightened risk of leukemia development. Owing to technical and sample size limitations, most CH studies have cha...

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Detalles Bibliográficos
Autores principales: Gao, Teng, Ptashkin, Ryan, Bolton, Kelly L., Sirenko, Maria, Fong, Christopher, Spitzer, Barbara, Menghrajani, Kamal, Ossa, Juan E. Arango, Zhou, Yangyu, Bernard, Elsa, Levine, Max, Martinez, Juan S. Medina, Zhang, Yanming, Franch-Expósito, Sebastià, Patel, Minal, Braunstein, Lior Z., Kelly, Daniel, Yabe, Mariko, Benayed, Ryma, Caltabellotta, Nicole M., Philip, John, Paraiso, Ederlinda, Mantha, Simon, Solit, David B., Diaz, Luis A., Berger, Michael F., Klimek, Virginia, Levine, Ross L., Zehir, Ahmet, Devlin, Sean M., Papaemmanuil, Elli
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7804935/
https://www.ncbi.nlm.nih.gov/pubmed/33436578
http://dx.doi.org/10.1038/s41467-020-20565-7

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