Nanoparticle delivery of microRNA-146a regulates mechanotransduction in lung macrophages and mitigates injury during mechanical ventilation

Mechanical ventilation generates injurious forces that exacerbate lung injury. These forces disrupt lung barrier integrity, trigger proinflammatory mediator release, and differentially regulate genes and non-coding oligonucleotides including microRNAs. In this study, we identify miR-146a as a mechan...

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Detalles Bibliográficos
Autores principales: Bobba, Christopher M., Fei, Qinqin, Shukla, Vasudha, Lee, Hyunwook, Patel, Pragi, Putman, Rachel K., Spitzer, Carleen, Tsai, MuChun, Wewers, Mark D., Lee, Robert J., Christman, John W., Ballinger, Megan N., Ghadiali, Samir N., Englert, Joshua A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7804938/
https://www.ncbi.nlm.nih.gov/pubmed/33436554
http://dx.doi.org/10.1038/s41467-020-20449-w

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