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Clinical predictors of pathological good response in locally advanced rectal cancer

PURPOSE: The aim of this study was to identify the clinical predictors of pathological good response (PGR) after neoadjuvant chemoradiotherapy (nCRT) in locally advanced rectal cancer (LARC) to clarify the indications for local excision. METHODS AND MATERIALS: A total of 173 patients with LARC (cT3–...

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Autores principales: Shao, Kongfeng, Zheng, Rong, Li, Anchuan, Li, Xiaobo, Xu, Benhua
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7805032/
https://www.ncbi.nlm.nih.gov/pubmed/33436026
http://dx.doi.org/10.1186/s13014-020-01741-x
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author Shao, Kongfeng
Zheng, Rong
Li, Anchuan
Li, Xiaobo
Xu, Benhua
author_facet Shao, Kongfeng
Zheng, Rong
Li, Anchuan
Li, Xiaobo
Xu, Benhua
author_sort Shao, Kongfeng
collection PubMed
description PURPOSE: The aim of this study was to identify the clinical predictors of pathological good response (PGR) after neoadjuvant chemoradiotherapy (nCRT) in locally advanced rectal cancer (LARC) to clarify the indications for local excision. METHODS AND MATERIALS: A total of 173 patients with LARC (cT3–4/N +) who were treated with nCRT followed by surgery were enrolled in our retrospective study. Patients were categorized into two groups according to the different tumor responses of surgical pathology. Stage ypT0–1N0 was defined as the group with PGR, and stage ypT2–4N0/ypTanyN + was the defined as the pathological poor response (PPR) group, and the potential predictors were compared. RESULTS: Of 173 patients, PGR was achieved in 57 patients (32.95%). The distance from the inferior margin of the tumor to the anal verge, cT classification, pretreatment carcinoembryonic antigen (CEA) and the interval from the end of radiation to surgery were correlated with pathological response. In the multivariate analysis, the distance from anal verge < 5 cm (OR = 0.443, p = 0.019), pretreatment CEA < 5 ng/mL (OR = 0.412, p = 0.015) and the interval from the end of radiation to surgery ≥ 84 days (OR = 2.652, p = 0.005) were independent predictors of PGR. CONCLUSIONS: The distance from the inferior margin of the tumor to the anal verge, pretreatment CEA and the interval from the end of radiation to surgery were significant predictors of PGR in LARC. A prospective study is needed to further validate these results in the future.
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spelling pubmed-78050322021-01-14 Clinical predictors of pathological good response in locally advanced rectal cancer Shao, Kongfeng Zheng, Rong Li, Anchuan Li, Xiaobo Xu, Benhua Radiat Oncol Research PURPOSE: The aim of this study was to identify the clinical predictors of pathological good response (PGR) after neoadjuvant chemoradiotherapy (nCRT) in locally advanced rectal cancer (LARC) to clarify the indications for local excision. METHODS AND MATERIALS: A total of 173 patients with LARC (cT3–4/N +) who were treated with nCRT followed by surgery were enrolled in our retrospective study. Patients were categorized into two groups according to the different tumor responses of surgical pathology. Stage ypT0–1N0 was defined as the group with PGR, and stage ypT2–4N0/ypTanyN + was the defined as the pathological poor response (PPR) group, and the potential predictors were compared. RESULTS: Of 173 patients, PGR was achieved in 57 patients (32.95%). The distance from the inferior margin of the tumor to the anal verge, cT classification, pretreatment carcinoembryonic antigen (CEA) and the interval from the end of radiation to surgery were correlated with pathological response. In the multivariate analysis, the distance from anal verge < 5 cm (OR = 0.443, p = 0.019), pretreatment CEA < 5 ng/mL (OR = 0.412, p = 0.015) and the interval from the end of radiation to surgery ≥ 84 days (OR = 2.652, p = 0.005) were independent predictors of PGR. CONCLUSIONS: The distance from the inferior margin of the tumor to the anal verge, pretreatment CEA and the interval from the end of radiation to surgery were significant predictors of PGR in LARC. A prospective study is needed to further validate these results in the future. BioMed Central 2021-01-13 /pmc/articles/PMC7805032/ /pubmed/33436026 http://dx.doi.org/10.1186/s13014-020-01741-x Text en © The Author(s) 2021 Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Research
Shao, Kongfeng
Zheng, Rong
Li, Anchuan
Li, Xiaobo
Xu, Benhua
Clinical predictors of pathological good response in locally advanced rectal cancer
title Clinical predictors of pathological good response in locally advanced rectal cancer
title_full Clinical predictors of pathological good response in locally advanced rectal cancer
title_fullStr Clinical predictors of pathological good response in locally advanced rectal cancer
title_full_unstemmed Clinical predictors of pathological good response in locally advanced rectal cancer
title_short Clinical predictors of pathological good response in locally advanced rectal cancer
title_sort clinical predictors of pathological good response in locally advanced rectal cancer
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7805032/
https://www.ncbi.nlm.nih.gov/pubmed/33436026
http://dx.doi.org/10.1186/s13014-020-01741-x
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