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Evaluating distal renal tubular acidification function in primary hyperparathyroidism and its effects on bone mineral density

BACKGROUND: Primary hyperparathyroidism (PHPT) is a common endocrinopathy that may increase fracture risk and decrease bone mineral density (BMD). Some patients develop distal renal tubular acidification dysfunction under conditions of hyperchloraemia or hyperchloraemic acidosis. To examine whether...

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Autores principales: Tang, Wangna, Jia, Hongwei, Wang, Baoping, Chai, Yun, Liu, Tong, Wang, Hao, Dai, Chenlin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7805182/
https://www.ncbi.nlm.nih.gov/pubmed/33435934
http://dx.doi.org/10.1186/s12891-021-03954-x
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author Tang, Wangna
Jia, Hongwei
Wang, Baoping
Chai, Yun
Liu, Tong
Wang, Hao
Dai, Chenlin
author_facet Tang, Wangna
Jia, Hongwei
Wang, Baoping
Chai, Yun
Liu, Tong
Wang, Hao
Dai, Chenlin
author_sort Tang, Wangna
collection PubMed
description BACKGROUND: Primary hyperparathyroidism (PHPT) is a common endocrinopathy that may increase fracture risk and decrease bone mineral density (BMD). Some patients develop distal renal tubular acidification dysfunction under conditions of hyperchloraemia or hyperchloraemic acidosis. To examine whether this dysfunction influences the clinical outcome, we explored the distal renal tubular acidification function in patients with PHPT and its effects on the clinical manifestations of the disease. METHODS: We retrospectively analysed 75 PHPT patients with regard to renal tubular acidification and blood gas analysis. The patients were divided into two groups, the renal tubular acidification dysfunction group and normal function group. RESULTS: Serum phosphate level and total hip bone density were significantly decreased and 25OHD level was significantly increased in the renal tubular acidification dysfunction group in comparison to the normal function group. Female patients in the renal tubular acidification dysfunction group showed significantly decreased femoral neck and total hip BMD and increased susceptibility to fracture. However, there were no such differences in male patients between the two groups. CONCLUSIONS: About 54.6 % of PHPT patients in our study population had abnormal distal renal tubular acidification. PHPT patients with abnormal distal renal tubular acidification may have lower hip bone density. Female PHPT patients with abnormal distal renal tubular acidification showed increased susceptibility to fractures and the development of osteoporosis.
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spelling pubmed-78051822021-01-14 Evaluating distal renal tubular acidification function in primary hyperparathyroidism and its effects on bone mineral density Tang, Wangna Jia, Hongwei Wang, Baoping Chai, Yun Liu, Tong Wang, Hao Dai, Chenlin BMC Musculoskelet Disord Research Article BACKGROUND: Primary hyperparathyroidism (PHPT) is a common endocrinopathy that may increase fracture risk and decrease bone mineral density (BMD). Some patients develop distal renal tubular acidification dysfunction under conditions of hyperchloraemia or hyperchloraemic acidosis. To examine whether this dysfunction influences the clinical outcome, we explored the distal renal tubular acidification function in patients with PHPT and its effects on the clinical manifestations of the disease. METHODS: We retrospectively analysed 75 PHPT patients with regard to renal tubular acidification and blood gas analysis. The patients were divided into two groups, the renal tubular acidification dysfunction group and normal function group. RESULTS: Serum phosphate level and total hip bone density were significantly decreased and 25OHD level was significantly increased in the renal tubular acidification dysfunction group in comparison to the normal function group. Female patients in the renal tubular acidification dysfunction group showed significantly decreased femoral neck and total hip BMD and increased susceptibility to fracture. However, there were no such differences in male patients between the two groups. CONCLUSIONS: About 54.6 % of PHPT patients in our study population had abnormal distal renal tubular acidification. PHPT patients with abnormal distal renal tubular acidification may have lower hip bone density. Female PHPT patients with abnormal distal renal tubular acidification showed increased susceptibility to fractures and the development of osteoporosis. BioMed Central 2021-01-12 /pmc/articles/PMC7805182/ /pubmed/33435934 http://dx.doi.org/10.1186/s12891-021-03954-x Text en © The Author(s) 2021 Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Research Article
Tang, Wangna
Jia, Hongwei
Wang, Baoping
Chai, Yun
Liu, Tong
Wang, Hao
Dai, Chenlin
Evaluating distal renal tubular acidification function in primary hyperparathyroidism and its effects on bone mineral density
title Evaluating distal renal tubular acidification function in primary hyperparathyroidism and its effects on bone mineral density
title_full Evaluating distal renal tubular acidification function in primary hyperparathyroidism and its effects on bone mineral density
title_fullStr Evaluating distal renal tubular acidification function in primary hyperparathyroidism and its effects on bone mineral density
title_full_unstemmed Evaluating distal renal tubular acidification function in primary hyperparathyroidism and its effects on bone mineral density
title_short Evaluating distal renal tubular acidification function in primary hyperparathyroidism and its effects on bone mineral density
title_sort evaluating distal renal tubular acidification function in primary hyperparathyroidism and its effects on bone mineral density
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7805182/
https://www.ncbi.nlm.nih.gov/pubmed/33435934
http://dx.doi.org/10.1186/s12891-021-03954-x
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