Myeloid-derived suppressor cells in gastrointestinal cancers: A systemic review

Gastrointestinal (GI) cancers are one of the most common malignancies worldwide, with high rates of morbidity and mortality. Myeloid-derived suppressor cells (MDSCs) are major components of the tumor microenvironment (TME). MDSCs facilitate the transformation of premalignant cells and play roles in...

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Detalles Bibliográficos
Autores principales: Farshidpour, Maham, Ahmed, Monjur, Junna, Shilpa, Merchant, Juanita L
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Baishideng Publishing Group Inc 2021
Materias:
Therapeutic and Diagnostic Guidelines
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7805271/
https://www.ncbi.nlm.nih.gov/pubmed/33510845
http://dx.doi.org/10.4251/wjgo.v13.i1.1
Descripción
Sumario:Gastrointestinal (GI) cancers are one of the most common malignancies worldwide, with high rates of morbidity and mortality. Myeloid-derived suppressor cells (MDSCs) are major components of the tumor microenvironment (TME). MDSCs facilitate the transformation of premalignant cells and play roles in tumor growth and metastasis. Moreover, in patients with GI malignancies, MDSCs can lead to the suppression of T cells and natural killer cells. Accordingly, a better understanding of the role and mechanism of action of MDSCs in the TME will aid in the development of novel immune-targeted therapies.

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