Myeloid-derived suppressor cells in gastrointestinal cancers: A systemic review

Gastrointestinal (GI) cancers are one of the most common malignancies worldwide, with high rates of morbidity and mortality. Myeloid-derived suppressor cells (MDSCs) are major components of the tumor microenvironment (TME). MDSCs facilitate the transformation of premalignant cells and play roles in...

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Autores principales: Farshidpour, Maham, Ahmed, Monjur, Junna, Shilpa, Merchant, Juanita L
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Baishideng Publishing Group Inc 2021
Materias:
Therapeutic and Diagnostic Guidelines
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7805271/
https://www.ncbi.nlm.nih.gov/pubmed/33510845
http://dx.doi.org/10.4251/wjgo.v13.i1.1
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author Farshidpour, Maham
Ahmed, Monjur
Junna, Shilpa
Merchant, Juanita L
author_facet Farshidpour, Maham
Ahmed, Monjur
Junna, Shilpa
Merchant, Juanita L
author_sort Farshidpour, Maham
collection PubMed
description Gastrointestinal (GI) cancers are one of the most common malignancies worldwide, with high rates of morbidity and mortality. Myeloid-derived suppressor cells (MDSCs) are major components of the tumor microenvironment (TME). MDSCs facilitate the transformation of premalignant cells and play roles in tumor growth and metastasis. Moreover, in patients with GI malignancies, MDSCs can lead to the suppression of T cells and natural killer cells. Accordingly, a better understanding of the role and mechanism of action of MDSCs in the TME will aid in the development of novel immune-targeted therapies.
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spelling pubmed-78052712021-01-27 Myeloid-derived suppressor cells in gastrointestinal cancers: A systemic review Farshidpour, Maham Ahmed, Monjur Junna, Shilpa Merchant, Juanita L World J Gastrointest Oncol Therapeutic and Diagnostic Guidelines Gastrointestinal (GI) cancers are one of the most common malignancies worldwide, with high rates of morbidity and mortality. Myeloid-derived suppressor cells (MDSCs) are major components of the tumor microenvironment (TME). MDSCs facilitate the transformation of premalignant cells and play roles in tumor growth and metastasis. Moreover, in patients with GI malignancies, MDSCs can lead to the suppression of T cells and natural killer cells. Accordingly, a better understanding of the role and mechanism of action of MDSCs in the TME will aid in the development of novel immune-targeted therapies. Baishideng Publishing Group Inc 2021-01-15 2021-01-15 /pmc/articles/PMC7805271/ /pubmed/33510845 http://dx.doi.org/10.4251/wjgo.v13.i1.1 Text en ©The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved. http://creativecommons.org/licenses/by-nc/4.0/ This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
spellingShingle Therapeutic and Diagnostic Guidelines
Farshidpour, Maham
Ahmed, Monjur
Junna, Shilpa
Merchant, Juanita L
Myeloid-derived suppressor cells in gastrointestinal cancers: A systemic review
title Myeloid-derived suppressor cells in gastrointestinal cancers: A systemic review
title_full Myeloid-derived suppressor cells in gastrointestinal cancers: A systemic review
title_fullStr Myeloid-derived suppressor cells in gastrointestinal cancers: A systemic review
title_full_unstemmed Myeloid-derived suppressor cells in gastrointestinal cancers: A systemic review
title_short Myeloid-derived suppressor cells in gastrointestinal cancers: A systemic review
title_sort myeloid-derived suppressor cells in gastrointestinal cancers: a systemic review
topic Therapeutic and Diagnostic Guidelines
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7805271/
https://www.ncbi.nlm.nih.gov/pubmed/33510845
http://dx.doi.org/10.4251/wjgo.v13.i1.1
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