Tetherin antagonism by SARS-CoV-2 enhances virus release: multiple mechanisms including ORF3a-mediated defective retrograde traffic

The antiviral restriction factor, tetherin, blocks the release of several different families of enveloped viruses, including the Coronaviridae. Tetherin is an interferon-induced protein that forms parallel homodimers between the host cell and viral particles, linking viruses to the surface of infect...

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Detalles Bibliográficos
Autores principales: Stewart, Hazel, Palmulli, Roberta, Johansen, Kristoffer H., McGovern, Naomi, Shehata, Ola M., Carnell, George W., Jackson, Hannah K., Lee, Jin S., Brown, Jonathan C., Burgoyne, Thomas, Heeney, Jonathan L., Okkenhaug, Klaus, Firth, Andrew E., Peden, Andrew A., Edgar, James R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7805449/
https://www.ncbi.nlm.nih.gov/pubmed/33442692
http://dx.doi.org/10.1101/2021.01.06.425396

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