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Lipidomic Signatures Align with Inflammatory Patterns and Outcomes in Critical Illness

Alterations in lipid metabolism have the potential to be markers as well as drivers of the pathobiology of acute critical illness. Here, we took advantage of the temporal precision offered by trauma as a common cause of critical illness to identify the dynamic patterns in the circulating lipidome in...

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Autores principales: Wu, Junru, Cyr, Anthony, Gruen, Danielle S., Lovelace, Tyler C., Benos, Panayiotis V., Chen, Tianmeng, Guyette, Francis X., Yazer, Mark H., Daley, Brian J., Miller, Richard S., Harbrecht, Brian G., Claridge, Jeffrey A., Phelan, Herb A., Zuckerbraun, Brian S., Neal, Matthew D., Johansson, Pär I., Stensballe, Jakob, Namas, Rami A., Vodovotz, Yoram, Sperry, Jason L., Billiar, Timothy R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Journal Experts 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7805459/
https://www.ncbi.nlm.nih.gov/pubmed/33442677
http://dx.doi.org/10.21203/rs.3.rs-106579/v1
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author Wu, Junru
Cyr, Anthony
Gruen, Danielle S.
Lovelace, Tyler C.
Benos, Panayiotis V.
Chen, Tianmeng
Guyette, Francis X.
Yazer, Mark H.
Daley, Brian J.
Miller, Richard S.
Harbrecht, Brian G.
Claridge, Jeffrey A.
Phelan, Herb A.
Zuckerbraun, Brian S.
Neal, Matthew D.
Johansson, Pär I.
Stensballe, Jakob
Namas, Rami A.
Vodovotz, Yoram
Sperry, Jason L.
Billiar, Timothy R.
author_facet Wu, Junru
Cyr, Anthony
Gruen, Danielle S.
Lovelace, Tyler C.
Benos, Panayiotis V.
Chen, Tianmeng
Guyette, Francis X.
Yazer, Mark H.
Daley, Brian J.
Miller, Richard S.
Harbrecht, Brian G.
Claridge, Jeffrey A.
Phelan, Herb A.
Zuckerbraun, Brian S.
Neal, Matthew D.
Johansson, Pär I.
Stensballe, Jakob
Namas, Rami A.
Vodovotz, Yoram
Sperry, Jason L.
Billiar, Timothy R.
author_sort Wu, Junru
collection PubMed
description Alterations in lipid metabolism have the potential to be markers as well as drivers of the pathobiology of acute critical illness. Here, we took advantage of the temporal precision offered by trauma as a common cause of critical illness to identify the dynamic patterns in the circulating lipidome in critically ill humans. The major findings include an early loss of all classes of circulating lipids followed by a delayed and selective lipogenesis in patients destined to remain critically ill. Early in the clinical course, Fresh Frozen Plasma administration led to improved survival in association with preserved lipid levels that related to favorable changes in coagulation and inflammation biomarkers. Late over-representation of phosphatidylethanolamines with critical illness led to the validation of a Lipid Reprogramming Score that was prognostic not only in trauma but also severe COVID-19 patients. Our lipidomic findings provide a new paradigm for the lipid response underlying critical illness.
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spelling pubmed-78054592021-01-14 Lipidomic Signatures Align with Inflammatory Patterns and Outcomes in Critical Illness Wu, Junru Cyr, Anthony Gruen, Danielle S. Lovelace, Tyler C. Benos, Panayiotis V. Chen, Tianmeng Guyette, Francis X. Yazer, Mark H. Daley, Brian J. Miller, Richard S. Harbrecht, Brian G. Claridge, Jeffrey A. Phelan, Herb A. Zuckerbraun, Brian S. Neal, Matthew D. Johansson, Pär I. Stensballe, Jakob Namas, Rami A. Vodovotz, Yoram Sperry, Jason L. Billiar, Timothy R. Res Sq Article Alterations in lipid metabolism have the potential to be markers as well as drivers of the pathobiology of acute critical illness. Here, we took advantage of the temporal precision offered by trauma as a common cause of critical illness to identify the dynamic patterns in the circulating lipidome in critically ill humans. The major findings include an early loss of all classes of circulating lipids followed by a delayed and selective lipogenesis in patients destined to remain critically ill. Early in the clinical course, Fresh Frozen Plasma administration led to improved survival in association with preserved lipid levels that related to favorable changes in coagulation and inflammation biomarkers. Late over-representation of phosphatidylethanolamines with critical illness led to the validation of a Lipid Reprogramming Score that was prognostic not only in trauma but also severe COVID-19 patients. Our lipidomic findings provide a new paradigm for the lipid response underlying critical illness. American Journal Experts 2021-01-08 /pmc/articles/PMC7805459/ /pubmed/33442677 http://dx.doi.org/10.21203/rs.3.rs-106579/v1 Text en https://creativecommons.org/licenses/by/4.0/This work is licensed under a Creative Commons Attribution 4.0 International License (https://creativecommons.org/licenses/by/4.0/) , which allows reusers to distribute, remix, adapt, and build upon the material in any medium or format, so long as attribution is given to the creator. The license allows for commercial use.
spellingShingle Article
Wu, Junru
Cyr, Anthony
Gruen, Danielle S.
Lovelace, Tyler C.
Benos, Panayiotis V.
Chen, Tianmeng
Guyette, Francis X.
Yazer, Mark H.
Daley, Brian J.
Miller, Richard S.
Harbrecht, Brian G.
Claridge, Jeffrey A.
Phelan, Herb A.
Zuckerbraun, Brian S.
Neal, Matthew D.
Johansson, Pär I.
Stensballe, Jakob
Namas, Rami A.
Vodovotz, Yoram
Sperry, Jason L.
Billiar, Timothy R.
Lipidomic Signatures Align with Inflammatory Patterns and Outcomes in Critical Illness
title Lipidomic Signatures Align with Inflammatory Patterns and Outcomes in Critical Illness
title_full Lipidomic Signatures Align with Inflammatory Patterns and Outcomes in Critical Illness
title_fullStr Lipidomic Signatures Align with Inflammatory Patterns and Outcomes in Critical Illness
title_full_unstemmed Lipidomic Signatures Align with Inflammatory Patterns and Outcomes in Critical Illness
title_short Lipidomic Signatures Align with Inflammatory Patterns and Outcomes in Critical Illness
title_sort lipidomic signatures align with inflammatory patterns and outcomes in critical illness
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7805459/
https://www.ncbi.nlm.nih.gov/pubmed/33442677
http://dx.doi.org/10.21203/rs.3.rs-106579/v1
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