Human Penile Ossification: A Rare Cause of Sexual Dysfunction – A Case Report and Review of the Literature

Human penile ossification is a rare urologic condition with approximately 40 cases reported in the literature so far. While bone is essential for penetrative intercourse in many non-human mammals, human penile ossification appears to be part of a metaplastic process occurring after injury or trauma. Conditions such as Peyronie’s disease, diabetes mellitus, local trauma, and end-stage renal disease have been associated with this entity. We report the case of a 65-year-old male with penile curvature and a history of painful intercourse who underwent partial excision and grafting with bovine pericardial graft and was found on pathologic examination to have penile ossification.