Treatment of Statin-Induced Necrotizing Autoimmune Myopathy With Glucocorticoid Monotherapy

Statins are widely prescribed medications to prevent cardiovascular events such as myocardial infarction and stroke. Both myalgia and myopathy are well-known potential side effects of statins. However, a rare and severe form of statin-induced necrotizing autoimmune myopathy (SINAM) has recently been...

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Detalles Bibliográficos
Autores principales: Lempel, Matthew, Molla, Ermal
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cureus 2020
Materias:
Internal Medicine
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7805509/
https://www.ncbi.nlm.nih.gov/pubmed/33489504
http://dx.doi.org/10.7759/cureus.12086
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author Lempel, Matthew
Molla, Ermal
author_facet Lempel, Matthew
Molla, Ermal
author_sort Lempel, Matthew
collection PubMed
description Statins are widely prescribed medications to prevent cardiovascular events such as myocardial infarction and stroke. Both myalgia and myopathy are well-known potential side effects of statins. However, a rare and severe form of statin-induced necrotizing autoimmune myopathy (SINAM) has recently been described and can lead to debilitating weakness, often requiring immunosuppressive therapy. We report a case of a 73-year-old male who made a complete recovery from SINAM following a three-month course of prednisone monotherapy.
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spelling pubmed-78055092021-01-21 Treatment of Statin-Induced Necrotizing Autoimmune Myopathy With Glucocorticoid Monotherapy Lempel, Matthew Molla, Ermal Cureus Internal Medicine Statins are widely prescribed medications to prevent cardiovascular events such as myocardial infarction and stroke. Both myalgia and myopathy are well-known potential side effects of statins. However, a rare and severe form of statin-induced necrotizing autoimmune myopathy (SINAM) has recently been described and can lead to debilitating weakness, often requiring immunosuppressive therapy. We report a case of a 73-year-old male who made a complete recovery from SINAM following a three-month course of prednisone monotherapy. Cureus 2020-12-14 /pmc/articles/PMC7805509/ /pubmed/33489504 http://dx.doi.org/10.7759/cureus.12086 Text en Copyright © 2020, Lempel et al. http://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Internal Medicine
Lempel, Matthew
Molla, Ermal
Treatment of Statin-Induced Necrotizing Autoimmune Myopathy With Glucocorticoid Monotherapy
title Treatment of Statin-Induced Necrotizing Autoimmune Myopathy With Glucocorticoid Monotherapy
title_full Treatment of Statin-Induced Necrotizing Autoimmune Myopathy With Glucocorticoid Monotherapy
title_fullStr Treatment of Statin-Induced Necrotizing Autoimmune Myopathy With Glucocorticoid Monotherapy
title_full_unstemmed Treatment of Statin-Induced Necrotizing Autoimmune Myopathy With Glucocorticoid Monotherapy
title_short Treatment of Statin-Induced Necrotizing Autoimmune Myopathy With Glucocorticoid Monotherapy
title_sort treatment of statin-induced necrotizing autoimmune myopathy with glucocorticoid monotherapy
topic Internal Medicine
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7805509/
https://www.ncbi.nlm.nih.gov/pubmed/33489504
http://dx.doi.org/10.7759/cureus.12086
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