Cryptococcal Meningoencephalitis 10 Years After Bone Marrow Transplant in a Patient With Multiple Myeloma

Cryptococcosis is a fungal infection that mostly affects immunocompromised patients. Diagnosis is based on the detection of cryptococcal antigen in the cerebrospinal fluid (CSF) or serum. Antifungal resistance is emerging, making treatment difficult and long. We report a case of cryptococcosis in a...

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Autores principales: Stepman, Gauthier, Sanapati, Jaya, Dabb, Kulveer, Angelo, Debra, Frunzi, Johnathan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cureus 2020
Materias:
Internal Medicine
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7805512/
https://www.ncbi.nlm.nih.gov/pubmed/33489511
http://dx.doi.org/10.7759/cureus.12094
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author Stepman, Gauthier
Sanapati, Jaya
Dabb, Kulveer
Angelo, Debra
Frunzi, Johnathan
author_facet Stepman, Gauthier
Sanapati, Jaya
Dabb, Kulveer
Angelo, Debra
Frunzi, Johnathan
author_sort Stepman, Gauthier
collection PubMed
description Cryptococcosis is a fungal infection that mostly affects immunocompromised patients. Diagnosis is based on the detection of cryptococcal antigen in the cerebrospinal fluid (CSF) or serum. Antifungal resistance is emerging, making treatment difficult and long. We report a case of cryptococcosis in a patient with multiple myeloma, years after undergoing a bone marrow transplant. Symptoms were mild, and imaging studies were nonspecific. CSF analysis revealed positive cryptococcal antigen. The patient was started on the standard three-phase antifungal therapy and recovered.
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spelling pubmed-78055122021-01-21 Cryptococcal Meningoencephalitis 10 Years After Bone Marrow Transplant in a Patient With Multiple Myeloma Stepman, Gauthier Sanapati, Jaya Dabb, Kulveer Angelo, Debra Frunzi, Johnathan Cureus Internal Medicine Cryptococcosis is a fungal infection that mostly affects immunocompromised patients. Diagnosis is based on the detection of cryptococcal antigen in the cerebrospinal fluid (CSF) or serum. Antifungal resistance is emerging, making treatment difficult and long. We report a case of cryptococcosis in a patient with multiple myeloma, years after undergoing a bone marrow transplant. Symptoms were mild, and imaging studies were nonspecific. CSF analysis revealed positive cryptococcal antigen. The patient was started on the standard three-phase antifungal therapy and recovered. Cureus 2020-12-15 /pmc/articles/PMC7805512/ /pubmed/33489511 http://dx.doi.org/10.7759/cureus.12094 Text en Copyright © 2020, Stepman et al. http://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Internal Medicine
Stepman, Gauthier
Sanapati, Jaya
Dabb, Kulveer
Angelo, Debra
Frunzi, Johnathan
Cryptococcal Meningoencephalitis 10 Years After Bone Marrow Transplant in a Patient With Multiple Myeloma
title Cryptococcal Meningoencephalitis 10 Years After Bone Marrow Transplant in a Patient With Multiple Myeloma
title_full Cryptococcal Meningoencephalitis 10 Years After Bone Marrow Transplant in a Patient With Multiple Myeloma
title_fullStr Cryptococcal Meningoencephalitis 10 Years After Bone Marrow Transplant in a Patient With Multiple Myeloma
title_full_unstemmed Cryptococcal Meningoencephalitis 10 Years After Bone Marrow Transplant in a Patient With Multiple Myeloma
title_short Cryptococcal Meningoencephalitis 10 Years After Bone Marrow Transplant in a Patient With Multiple Myeloma
title_sort cryptococcal meningoencephalitis 10 years after bone marrow transplant in a patient with multiple myeloma
topic Internal Medicine
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7805512/
https://www.ncbi.nlm.nih.gov/pubmed/33489511
http://dx.doi.org/10.7759/cureus.12094
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