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Dexamethasone acutely suppresses the anabolic SNAT2/SLC38A2 amino acid transporter protein in L6‐G8C5 rat skeletal muscle cells

Chronic metabolic acidosis plays a role in cachexia by enhancing total proteolysis in skeletal muscle. Glucocorticoid also triggers proteolysis and plays a permissive role in the effect of acidosis. The System A amino acid transporter SNAT2/SLC38A2 is ubiquitously expressed in mammalian cells includ...

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Detalles Bibliográficos
Autores principales:	Blbas, Safia, Watson, Emma, Butler, Heather, Brown, Jeremy, Herbert, Terence P., Stover, Cordula M., Bevington, Alan, Abbasian, Nima
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2020
Materias:	Research Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7805547/ https://www.ncbi.nlm.nih.gov/pubmed/33490882 http://dx.doi.org/10.1096/fba.2020-00076

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