SIRT1 is downregulated by autophagy in senescence and aging

SIRT1 (Sir2) is an NAD(+)-dependent deacetylase that plays critical roles in a broad range of biological events, including metabolism, immune response, and aging(1–5). While there is strong interest in stimulating SIRT1 catalytic activity, the homeostasis of SIRT1 at the protein level is poorly unde...

Descripción completa

Detalles Bibliográficos
Autores principales: Xu, Caiyue, Wang, Lu, Fozouni, Parinaz, Evjen, Gry, Chandra, Vemika, Jiang, Jing, Lu, Congcong, Nicastri, Michael, Bretz, Corey, Winkler, Jeffrey D., Amaravadi, Ravi, Garcia, Benjamin A., Adams, Peter D., Ott, Melanie, Tong, Wei, Johansen, Terje, Dou, Zhixun, Berger, Shelley L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7805578/
https://www.ncbi.nlm.nih.gov/pubmed/32989246
http://dx.doi.org/10.1038/s41556-020-00579-5

Ejemplares similares

Ejemplares similares