Immediate Infusion Reaction to Intravenous Ustekinumab in Three Crohn’s Disease Patients: A Case Report and Review of the Literature

Recently, ustekinumab has been approved for the treatment of Crohn’s disease and ulcerative colitis. Treatment is started with an intravenous induction dose, followed by a subcutaneous dosage. We present details of three patients with therapy-refractory Crohn’s disease who experienced an immediate i...

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Detalles Bibliográficos
Autores principales: Thomas, Pepijn W A, Ferwerda, Gerben, West, Rachel L, Hoentjen, Frank
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2020
Materias:
Short Reports
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7805788/
https://www.ncbi.nlm.nih.gov/pubmed/32588044
http://dx.doi.org/10.1093/ecco-jcc/jjaa115
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author Thomas, Pepijn W A
Ferwerda, Gerben
West, Rachel L
Hoentjen, Frank
author_facet Thomas, Pepijn W A
Ferwerda, Gerben
West, Rachel L
Hoentjen, Frank
author_sort Thomas, Pepijn W A
collection PubMed
description Recently, ustekinumab has been approved for the treatment of Crohn’s disease and ulcerative colitis. Treatment is started with an intravenous induction dose, followed by a subcutaneous dosage. We present details of three patients with therapy-refractory Crohn’s disease who experienced an immediate infusion reaction to intravenous administration of ustekinumab. In two of these patients a subsequent reaction to subcutaneous injections occurred. Clinical features and pathophysiology are discussed.
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spelling pubmed-78057882021-01-18 Immediate Infusion Reaction to Intravenous Ustekinumab in Three Crohn’s Disease Patients: A Case Report and Review of the Literature Thomas, Pepijn W A Ferwerda, Gerben West, Rachel L Hoentjen, Frank J Crohns Colitis Short Reports Recently, ustekinumab has been approved for the treatment of Crohn’s disease and ulcerative colitis. Treatment is started with an intravenous induction dose, followed by a subcutaneous dosage. We present details of three patients with therapy-refractory Crohn’s disease who experienced an immediate infusion reaction to intravenous administration of ustekinumab. In two of these patients a subsequent reaction to subcutaneous injections occurred. Clinical features and pathophysiology are discussed. Oxford University Press 2020-06-26 /pmc/articles/PMC7805788/ /pubmed/32588044 http://dx.doi.org/10.1093/ecco-jcc/jjaa115 Text en © The Author(s) 2020. Published by Oxford University Press on behalf of European Crohn’s and Colitis Organisation. http://creativecommons.org/licenses/by-nc/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com
spellingShingle Short Reports
Thomas, Pepijn W A
Ferwerda, Gerben
West, Rachel L
Hoentjen, Frank
Immediate Infusion Reaction to Intravenous Ustekinumab in Three Crohn’s Disease Patients: A Case Report and Review of the Literature
title Immediate Infusion Reaction to Intravenous Ustekinumab in Three Crohn’s Disease Patients: A Case Report and Review of the Literature
title_full Immediate Infusion Reaction to Intravenous Ustekinumab in Three Crohn’s Disease Patients: A Case Report and Review of the Literature
title_fullStr Immediate Infusion Reaction to Intravenous Ustekinumab in Three Crohn’s Disease Patients: A Case Report and Review of the Literature
title_full_unstemmed Immediate Infusion Reaction to Intravenous Ustekinumab in Three Crohn’s Disease Patients: A Case Report and Review of the Literature
title_short Immediate Infusion Reaction to Intravenous Ustekinumab in Three Crohn’s Disease Patients: A Case Report and Review of the Literature
title_sort immediate infusion reaction to intravenous ustekinumab in three crohn’s disease patients: a case report and review of the literature
topic Short Reports
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7805788/
https://www.ncbi.nlm.nih.gov/pubmed/32588044
http://dx.doi.org/10.1093/ecco-jcc/jjaa115
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