TRAF6-IRF5 kinetics, TRIF, and biophysical factors drive synergistic innate responses to particle-mediated MPLA-CpG co-presentation

Innate immune responses to pathogens are driven by co-presentation of multiple pathogen-associated molecular patterns (PAMPs). Combinations of PAMPs can trigger synergistic immune responses, but the underlying molecular mechanisms of synergy are poorly understood. Here, we used synthetic particulate...

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Detalles Bibliográficos
Autores principales: Pradhan, P., Toy, R., Jhita, N., Atalis, A., Pandey, B., Beach, A., Blanchard, E. L., Moore, S. G., Gaul, D. A., Santangelo, P. J., Shayakhmetov, D. M., Roy, K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2021
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7806213/
https://www.ncbi.nlm.nih.gov/pubmed/33523878
http://dx.doi.org/10.1126/sciadv.abd4235

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