O-GlcNAcylation ameliorates the pathological manifestations of Alzheimer’s disease by inhibiting necroptosis

O-GlcNAcylation (O-linked β-N-acetylglucosaminylation) is notably decreased in Alzheimer’s disease (AD) brain. Necroptosis is activated in AD brain and is positively correlated with neuroinflammation and tau pathology. However, the links among altered O-GlcNAcylation, β-amyloid (Aβ) accumulation, an...

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Detalles Bibliográficos
Autores principales: Park, Jinsu, Ha, Hee-Jin, Chung, Eun Seon, Baek, Seung Hyun, Cho, Yoonsuk, Kim, Hark Kyun, Han, Jihoon, Sul, Jae Hoon, Lee, Jeongmi, Kim, Eunae, Kim, Junsik, Yang, Yong Ryoul, Park, Mikyoung, Kim, Sung Hyun, Arumugam, Thiruma V., Jang, Hyemin, Seo, Sang Won, Suh, Pann-Ghill, Jo, Dong-Gyu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2021
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7806231/
https://www.ncbi.nlm.nih.gov/pubmed/33523877
http://dx.doi.org/10.1126/sciadv.abd3207

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