Increased Fecal Neopterin Parallels Gastrointestinal Symptoms in COVID-19

INTRODUCTION: Coronavirus disease (COVID-19) has spread from Wuhan, China, and become a worldwide pandemic. Most patients display respiratory symptoms but up to 50% report gastrointestinal symptoms. Neopterin is a surrogate marker for viral inflammation, and its production by macrophages is driven b...

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Detalles Bibliográficos
Autores principales: Grabherr, Felix, Effenberger, Maria, Pedrini, Alisa, Mayr, Lisa, Schwärzler, Julian, Reider, Simon, Enrich, Barbara, Fritsche, Gernot, Wildner, Sophie, Bellmann-Weiler, Rosa, Weiss, Günter, Scholl-Bürgi, Sabine, Müller, Thomas, Moschen, Alexander, Adolph, Timon E., Tilg, Herbert
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wolters Kluwer 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7806232/
https://www.ncbi.nlm.nih.gov/pubmed/33438988
http://dx.doi.org/10.14309/ctg.0000000000000293
Descripción
Sumario:INTRODUCTION: Coronavirus disease (COVID-19) has spread from Wuhan, China, and become a worldwide pandemic. Most patients display respiratory symptoms but up to 50% report gastrointestinal symptoms. Neopterin is a surrogate marker for viral inflammation, and its production by macrophages is driven by interferon-γ. METHODS: We measured fecal neopterin in 37 hospitalized COVID-19 patients not requiring intensive care measures and 22 healthy controls. RESULTS: Fecal neopterin was elevated in stool samples from COVID-19 patients compared with that in samples from healthy controls. Especially, patients reporting gastrointestinal symptoms exhibited increased fecal neopterin values. DISCUSSION: COVID-19 is associated with an inflammatory immune response in the gastrointestinal tract.

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