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Bone Mineral Density Evolution and Its Determinants in Long-term Survivors of Childhood Acute Leukemia: A Leucémies Enfants Adolescents Study

This prospective study aimed to analyze determinants that can influence bone mineral density evolution in childhood acute leukemia survivors. Patients included were selected from the long-term follow-up LEA cohort and had dual energy radiograph absorptiometry scan between 10 and 18 years and after t...

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Autores principales: Tabone, Marie-Dominique, Kolta, Sami, Auquier, Pascal, Vercasson, Camille, Chastagner, Pascal, Kanold, Justyna, Rohrlich, Pierre-Simon, Bertrand, Yves, Baruchel, André, Plantaz, Dominique, Gandemer, Virginie, Ducassou, Stéphane, Petit, Arnaud, Paillard, Catherine, Leverger, Guy, Dalle, Jean-Hugues, Berbis, Julie, Roux, Christian, Michel, Gérard
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Lippincott Williams & Wilkins 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7806242/
https://www.ncbi.nlm.nih.gov/pubmed/33458594
http://dx.doi.org/10.1097/HS9.0000000000000518
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author Tabone, Marie-Dominique
Kolta, Sami
Auquier, Pascal
Vercasson, Camille
Chastagner, Pascal
Kanold, Justyna
Rohrlich, Pierre-Simon
Bertrand, Yves
Baruchel, André
Plantaz, Dominique
Gandemer, Virginie
Ducassou, Stéphane
Petit, Arnaud
Paillard, Catherine
Leverger, Guy
Dalle, Jean-Hugues
Berbis, Julie
Roux, Christian
Michel, Gérard
author_facet Tabone, Marie-Dominique
Kolta, Sami
Auquier, Pascal
Vercasson, Camille
Chastagner, Pascal
Kanold, Justyna
Rohrlich, Pierre-Simon
Bertrand, Yves
Baruchel, André
Plantaz, Dominique
Gandemer, Virginie
Ducassou, Stéphane
Petit, Arnaud
Paillard, Catherine
Leverger, Guy
Dalle, Jean-Hugues
Berbis, Julie
Roux, Christian
Michel, Gérard
author_sort Tabone, Marie-Dominique
collection PubMed
description This prospective study aimed to analyze determinants that can influence bone mineral density evolution in childhood acute leukemia survivors. Patients included were selected from the long-term follow-up LEA cohort and had dual energy radiograph absorptiometry scan between 10 and 18 years and after the age of 18. All scans were centrally reviewed. Bone mineral density was measured at the lumbar spine, femoral neck, total hip, and whole body, and expressed as z-score. Eighty-nine patients (female 39, lymphoblastic leukemia 68, relapse 25, hematopoietic stem cell transplantation 44, and mean age 15.4 and 20.1 years at the first and second scans, respectively) were studied. The first and second scan z-scores were significantly correlated (P < 10(−3)). Mean femoral neck and total hip z-scores improved significantly between the first and second scans, whereas no significant evolution occurred at the lumbar spine and whole-body level. On the second evaluation, 14.6% of patients had z-score <−2 at the lumbar spine and 4.3% at the femoral neck level. Gender, type of leukemia, transplantation, relapse, cumulative corticosteroid doses, or growth hormone deficiency did not have any significant impact on z-score variation. Younger age at diagnosis (≤8.5 years) proved an unfavorable risk factor for z-score evolution at the lumbar spine (P = 0.041); the trend did not reach statistical significance for metabolic syndrome (P = 0.054). At the femoral neck, both were associated with unfavorable z-score evolution (P = 0.003 and 0.025, respectively). Patients treated at a younger age and those with metabolic syndrome seem to be at higher risk of bone mineral density decline and should benefit from specific interventions.
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spelling pubmed-78062422021-01-14 Bone Mineral Density Evolution and Its Determinants in Long-term Survivors of Childhood Acute Leukemia: A Leucémies Enfants Adolescents Study Tabone, Marie-Dominique Kolta, Sami Auquier, Pascal Vercasson, Camille Chastagner, Pascal Kanold, Justyna Rohrlich, Pierre-Simon Bertrand, Yves Baruchel, André Plantaz, Dominique Gandemer, Virginie Ducassou, Stéphane Petit, Arnaud Paillard, Catherine Leverger, Guy Dalle, Jean-Hugues Berbis, Julie Roux, Christian Michel, Gérard Hemasphere Article This prospective study aimed to analyze determinants that can influence bone mineral density evolution in childhood acute leukemia survivors. Patients included were selected from the long-term follow-up LEA cohort and had dual energy radiograph absorptiometry scan between 10 and 18 years and after the age of 18. All scans were centrally reviewed. Bone mineral density was measured at the lumbar spine, femoral neck, total hip, and whole body, and expressed as z-score. Eighty-nine patients (female 39, lymphoblastic leukemia 68, relapse 25, hematopoietic stem cell transplantation 44, and mean age 15.4 and 20.1 years at the first and second scans, respectively) were studied. The first and second scan z-scores were significantly correlated (P < 10(−3)). Mean femoral neck and total hip z-scores improved significantly between the first and second scans, whereas no significant evolution occurred at the lumbar spine and whole-body level. On the second evaluation, 14.6% of patients had z-score <−2 at the lumbar spine and 4.3% at the femoral neck level. Gender, type of leukemia, transplantation, relapse, cumulative corticosteroid doses, or growth hormone deficiency did not have any significant impact on z-score variation. Younger age at diagnosis (≤8.5 years) proved an unfavorable risk factor for z-score evolution at the lumbar spine (P = 0.041); the trend did not reach statistical significance for metabolic syndrome (P = 0.054). At the femoral neck, both were associated with unfavorable z-score evolution (P = 0.003 and 0.025, respectively). Patients treated at a younger age and those with metabolic syndrome seem to be at higher risk of bone mineral density decline and should benefit from specific interventions. Lippincott Williams & Wilkins 2021-01-12 /pmc/articles/PMC7806242/ /pubmed/33458594 http://dx.doi.org/10.1097/HS9.0000000000000518 Text en Copyright © 2021 the Author(s). Published by Wolters Kluwer Health, Inc. on behalf of the European Hematology Association. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (CCBY-NC-ND) (https://creativecommons.org/licenses/by-nc-nd/4.0/) , where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially without permission from the journal.
spellingShingle Article
Tabone, Marie-Dominique
Kolta, Sami
Auquier, Pascal
Vercasson, Camille
Chastagner, Pascal
Kanold, Justyna
Rohrlich, Pierre-Simon
Bertrand, Yves
Baruchel, André
Plantaz, Dominique
Gandemer, Virginie
Ducassou, Stéphane
Petit, Arnaud
Paillard, Catherine
Leverger, Guy
Dalle, Jean-Hugues
Berbis, Julie
Roux, Christian
Michel, Gérard
Bone Mineral Density Evolution and Its Determinants in Long-term Survivors of Childhood Acute Leukemia: A Leucémies Enfants Adolescents Study
title Bone Mineral Density Evolution and Its Determinants in Long-term Survivors of Childhood Acute Leukemia: A Leucémies Enfants Adolescents Study
title_full Bone Mineral Density Evolution and Its Determinants in Long-term Survivors of Childhood Acute Leukemia: A Leucémies Enfants Adolescents Study
title_fullStr Bone Mineral Density Evolution and Its Determinants in Long-term Survivors of Childhood Acute Leukemia: A Leucémies Enfants Adolescents Study
title_full_unstemmed Bone Mineral Density Evolution and Its Determinants in Long-term Survivors of Childhood Acute Leukemia: A Leucémies Enfants Adolescents Study
title_short Bone Mineral Density Evolution and Its Determinants in Long-term Survivors of Childhood Acute Leukemia: A Leucémies Enfants Adolescents Study
title_sort bone mineral density evolution and its determinants in long-term survivors of childhood acute leukemia: a leucémies enfants adolescents study
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7806242/
https://www.ncbi.nlm.nih.gov/pubmed/33458594
http://dx.doi.org/10.1097/HS9.0000000000000518
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