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Prediction of Histologic Subtype and FNCLCC Grade by SUVmax Measured on (18)F-FDG PET/CT in Patients with Retroperitoneal Liposarcoma

This study aimed to evaluate the usefulness of maximum standardized uptake value (SUVmax) on (18)F-fluorodeoxyglucose positron emission tomography with computed tomography ((18)F-FDG PET/CT) in differentiating the subtypes and tumor grades of retroperitoneal liposarcoma (RPLS). The data of RPLS pati...

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Autores principales: Li, Cheng-Peng, Liu, Dao-Ning, Zhou, Ni-Na, Tian, Xiu-Yun, Wang, Zhen, Liu, Bo-Nan, Hao, Chun-Yi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7806371/
https://www.ncbi.nlm.nih.gov/pubmed/33505228
http://dx.doi.org/10.1155/2021/7191363
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author Li, Cheng-Peng
Liu, Dao-Ning
Zhou, Ni-Na
Tian, Xiu-Yun
Wang, Zhen
Liu, Bo-Nan
Hao, Chun-Yi
author_facet Li, Cheng-Peng
Liu, Dao-Ning
Zhou, Ni-Na
Tian, Xiu-Yun
Wang, Zhen
Liu, Bo-Nan
Hao, Chun-Yi
author_sort Li, Cheng-Peng
collection PubMed
description This study aimed to evaluate the usefulness of maximum standardized uptake value (SUVmax) on (18)F-fluorodeoxyglucose positron emission tomography with computed tomography ((18)F-FDG PET/CT) in differentiating the subtypes and tumor grades of retroperitoneal liposarcoma (RPLS). The data of RPLS patients who underwent surgical resection from November 2013 to December 2019 at the sarcoma center of our institute were reviewed. The demographics, clinical features, and SUVmax of 84 patients who underwent preoperative (18)F-FDG PET/CT scans were analyzed. Of these, 19 patients (22.6%) were with well-differentiated liposarcoma (WDLPS), 60 patients (71.4%) were with dedifferentiated liposarcoma (DDLPS), and 5 patients (6.0%) were with pleomorphic liposarcoma (PMLPS). The median SUVmax of WDLPS, DDLPS, and PMLPS groups was 2.8 (IQR: 1.9–3.2), 6.2 (IQR: 4.1–11.3), and 4.5 (IQR: 4.0–7.4). The ROC curve suggested 3.8 as an approximate cutoff value of SUVmax for distinguishing WDLPS and non-WDLPS (sensitivity = 0.769; specificity = 0.895). The median SUVmax for FNCLCC Grades 1, 2, and 3 of RPLS was 2.5 (IQR: 1.9–3.2), 4.5 (IQR: 3.2–6.7), and 9.0 (IQR: 6.0–13.3). The ROC curves suggest that SUVmax of ≤3.8 and >5.3 can be used for predicting FNCLCC Grades 1 and 3, respectively. The result showed that (18)F-FDG PET/CT exhibited high sensitivity and specificity for identifying the subtypes and FNCLCC grades of RPLS. Additionally, (18)F-FDG PET/CT might be a useful complementary imaging modality for guiding suitable biopsy location of RPLS.
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spelling pubmed-78063712021-01-26 Prediction of Histologic Subtype and FNCLCC Grade by SUVmax Measured on (18)F-FDG PET/CT in Patients with Retroperitoneal Liposarcoma Li, Cheng-Peng Liu, Dao-Ning Zhou, Ni-Na Tian, Xiu-Yun Wang, Zhen Liu, Bo-Nan Hao, Chun-Yi Contrast Media Mol Imaging Research Article This study aimed to evaluate the usefulness of maximum standardized uptake value (SUVmax) on (18)F-fluorodeoxyglucose positron emission tomography with computed tomography ((18)F-FDG PET/CT) in differentiating the subtypes and tumor grades of retroperitoneal liposarcoma (RPLS). The data of RPLS patients who underwent surgical resection from November 2013 to December 2019 at the sarcoma center of our institute were reviewed. The demographics, clinical features, and SUVmax of 84 patients who underwent preoperative (18)F-FDG PET/CT scans were analyzed. Of these, 19 patients (22.6%) were with well-differentiated liposarcoma (WDLPS), 60 patients (71.4%) were with dedifferentiated liposarcoma (DDLPS), and 5 patients (6.0%) were with pleomorphic liposarcoma (PMLPS). The median SUVmax of WDLPS, DDLPS, and PMLPS groups was 2.8 (IQR: 1.9–3.2), 6.2 (IQR: 4.1–11.3), and 4.5 (IQR: 4.0–7.4). The ROC curve suggested 3.8 as an approximate cutoff value of SUVmax for distinguishing WDLPS and non-WDLPS (sensitivity = 0.769; specificity = 0.895). The median SUVmax for FNCLCC Grades 1, 2, and 3 of RPLS was 2.5 (IQR: 1.9–3.2), 4.5 (IQR: 3.2–6.7), and 9.0 (IQR: 6.0–13.3). The ROC curves suggest that SUVmax of ≤3.8 and >5.3 can be used for predicting FNCLCC Grades 1 and 3, respectively. The result showed that (18)F-FDG PET/CT exhibited high sensitivity and specificity for identifying the subtypes and FNCLCC grades of RPLS. Additionally, (18)F-FDG PET/CT might be a useful complementary imaging modality for guiding suitable biopsy location of RPLS. Hindawi 2021-01-06 /pmc/articles/PMC7806371/ /pubmed/33505228 http://dx.doi.org/10.1155/2021/7191363 Text en Copyright © 2021 Cheng-Peng Li et al. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Li, Cheng-Peng
Liu, Dao-Ning
Zhou, Ni-Na
Tian, Xiu-Yun
Wang, Zhen
Liu, Bo-Nan
Hao, Chun-Yi
Prediction of Histologic Subtype and FNCLCC Grade by SUVmax Measured on (18)F-FDG PET/CT in Patients with Retroperitoneal Liposarcoma
title Prediction of Histologic Subtype and FNCLCC Grade by SUVmax Measured on (18)F-FDG PET/CT in Patients with Retroperitoneal Liposarcoma
title_full Prediction of Histologic Subtype and FNCLCC Grade by SUVmax Measured on (18)F-FDG PET/CT in Patients with Retroperitoneal Liposarcoma
title_fullStr Prediction of Histologic Subtype and FNCLCC Grade by SUVmax Measured on (18)F-FDG PET/CT in Patients with Retroperitoneal Liposarcoma
title_full_unstemmed Prediction of Histologic Subtype and FNCLCC Grade by SUVmax Measured on (18)F-FDG PET/CT in Patients with Retroperitoneal Liposarcoma
title_short Prediction of Histologic Subtype and FNCLCC Grade by SUVmax Measured on (18)F-FDG PET/CT in Patients with Retroperitoneal Liposarcoma
title_sort prediction of histologic subtype and fnclcc grade by suvmax measured on (18)f-fdg pet/ct in patients with retroperitoneal liposarcoma
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7806371/
https://www.ncbi.nlm.nih.gov/pubmed/33505228
http://dx.doi.org/10.1155/2021/7191363
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