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C7ORF41 Regulates Inflammation by Inhibiting NF-κB Signaling Pathway
Inflammation is an important biological process for eliciting immune responses against physiological and pathological stimuli. Inflammation must be efficiently regulated to ensure homeostasis in the body. Nuclear factor-kappa B (NF-κB) signaling is crucial for inflammatory and immune responses. Aber...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7806384/ https://www.ncbi.nlm.nih.gov/pubmed/33506033 http://dx.doi.org/10.1155/2021/7413605 |
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author | Zhou, Jinping Zhou, Quan Zhang, Tan Fan, Jingyi |
author_facet | Zhou, Jinping Zhou, Quan Zhang, Tan Fan, Jingyi |
author_sort | Zhou, Jinping |
collection | PubMed |
description | Inflammation is an important biological process for eliciting immune responses against physiological and pathological stimuli. Inflammation must be efficiently regulated to ensure homeostasis in the body. Nuclear factor-kappa B (NF-κB) signaling is crucial for inflammatory and immune responses. Aberrant activation of NF-κB signaling leads to development of numerous human diseases. In this study, we investigated the function of chromosome 7 open reading frame 41 (C7ORF41) in NF-κB signaling during inflammation. C7ORF41 was upregulated in cells stimulated with tumor necrosis factor-alpha or lipopolysaccharide. Moreover, overexpression of C7ORF41 inhibited the activation of NF-κB and decreased the expression of its downstream target genes. Notably, small hairpin RNA-mediated depletion of C7ORF41 increased the levels of downstream genes and enabled the activation of NF-κB. In conclusion, C7ORF41 negatively regulated inflammation via NF-κB signaling and p65 phosphorylation in vitro. These findings may help to diagnose and prognosticate inflammatory conditions and may help develop new strategies for the management of inflammation-related diseases. |
format | Online Article Text |
id | pubmed-7806384 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Hindawi |
record_format | MEDLINE/PubMed |
spelling | pubmed-78063842021-01-26 C7ORF41 Regulates Inflammation by Inhibiting NF-κB Signaling Pathway Zhou, Jinping Zhou, Quan Zhang, Tan Fan, Jingyi Biomed Res Int Research Article Inflammation is an important biological process for eliciting immune responses against physiological and pathological stimuli. Inflammation must be efficiently regulated to ensure homeostasis in the body. Nuclear factor-kappa B (NF-κB) signaling is crucial for inflammatory and immune responses. Aberrant activation of NF-κB signaling leads to development of numerous human diseases. In this study, we investigated the function of chromosome 7 open reading frame 41 (C7ORF41) in NF-κB signaling during inflammation. C7ORF41 was upregulated in cells stimulated with tumor necrosis factor-alpha or lipopolysaccharide. Moreover, overexpression of C7ORF41 inhibited the activation of NF-κB and decreased the expression of its downstream target genes. Notably, small hairpin RNA-mediated depletion of C7ORF41 increased the levels of downstream genes and enabled the activation of NF-κB. In conclusion, C7ORF41 negatively regulated inflammation via NF-κB signaling and p65 phosphorylation in vitro. These findings may help to diagnose and prognosticate inflammatory conditions and may help develop new strategies for the management of inflammation-related diseases. Hindawi 2021-01-06 /pmc/articles/PMC7806384/ /pubmed/33506033 http://dx.doi.org/10.1155/2021/7413605 Text en Copyright © 2021 Jinping Zhou et al. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Article Zhou, Jinping Zhou, Quan Zhang, Tan Fan, Jingyi C7ORF41 Regulates Inflammation by Inhibiting NF-κB Signaling Pathway |
title | C7ORF41 Regulates Inflammation by Inhibiting NF-κB Signaling Pathway |
title_full | C7ORF41 Regulates Inflammation by Inhibiting NF-κB Signaling Pathway |
title_fullStr | C7ORF41 Regulates Inflammation by Inhibiting NF-κB Signaling Pathway |
title_full_unstemmed | C7ORF41 Regulates Inflammation by Inhibiting NF-κB Signaling Pathway |
title_short | C7ORF41 Regulates Inflammation by Inhibiting NF-κB Signaling Pathway |
title_sort | c7orf41 regulates inflammation by inhibiting nf-κb signaling pathway |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7806384/ https://www.ncbi.nlm.nih.gov/pubmed/33506033 http://dx.doi.org/10.1155/2021/7413605 |
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