N(6)-methyladenosine as a biological and clinical determinant in colorectal cancer: progression and future direction

Colorectal cancer (CRC) is one of the most prevalent cancers and one of the leading causes of cancer death. Recent studies have provided evidence that N(6)-methyladenosine (m(6)A), the most abundant RNA modifications in eukaryote, performs many functions in RNA metabolism including translation, spli...

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Autores principales: Li, Jinming, Liang, Lei, Yang, Yongzhi, Li, Xinxiang, Ma, Yanlei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Ivyspring International Publisher 2021
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7806471/
https://www.ncbi.nlm.nih.gov/pubmed/33456561
http://dx.doi.org/10.7150/thno.52366
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author Li, Jinming
Liang, Lei
Yang, Yongzhi
Li, Xinxiang
Ma, Yanlei
author_facet Li, Jinming
Liang, Lei
Yang, Yongzhi
Li, Xinxiang
Ma, Yanlei
author_sort Li, Jinming
collection PubMed
description Colorectal cancer (CRC) is one of the most prevalent cancers and one of the leading causes of cancer death. Recent studies have provided evidence that N(6)-methyladenosine (m(6)A), the most abundant RNA modifications in eukaryote, performs many functions in RNA metabolism including translation, splicing, storage, trafficking and degradation. Aberrant regulation of m(6)A modification in mRNAs and noncoding RNAs found in CRC tissues is crucial for cancer formation, progression, invasion and metastasis. Further, m(6)A regulators and m(6)A-related RNAs may become promising biomarkers, prognosis predictors as well as therapeutic targets. Here, we review the biological and clinical roles of m(6)A modification in CRC, and discuss the potential of m(6)A in clinical translation.
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spelling pubmed-78064712021-01-15 N(6)-methyladenosine as a biological and clinical determinant in colorectal cancer: progression and future direction Li, Jinming Liang, Lei Yang, Yongzhi Li, Xinxiang Ma, Yanlei Theranostics Review Colorectal cancer (CRC) is one of the most prevalent cancers and one of the leading causes of cancer death. Recent studies have provided evidence that N(6)-methyladenosine (m(6)A), the most abundant RNA modifications in eukaryote, performs many functions in RNA metabolism including translation, splicing, storage, trafficking and degradation. Aberrant regulation of m(6)A modification in mRNAs and noncoding RNAs found in CRC tissues is crucial for cancer formation, progression, invasion and metastasis. Further, m(6)A regulators and m(6)A-related RNAs may become promising biomarkers, prognosis predictors as well as therapeutic targets. Here, we review the biological and clinical roles of m(6)A modification in CRC, and discuss the potential of m(6)A in clinical translation. Ivyspring International Publisher 2021-01-01 /pmc/articles/PMC7806471/ /pubmed/33456561 http://dx.doi.org/10.7150/thno.52366 Text en © The author(s) This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/). See http://ivyspring.com/terms for full terms and conditions.
spellingShingle Review
Li, Jinming
Liang, Lei
Yang, Yongzhi
Li, Xinxiang
Ma, Yanlei
N(6)-methyladenosine as a biological and clinical determinant in colorectal cancer: progression and future direction
title N(6)-methyladenosine as a biological and clinical determinant in colorectal cancer: progression and future direction
title_full N(6)-methyladenosine as a biological and clinical determinant in colorectal cancer: progression and future direction
title_fullStr N(6)-methyladenosine as a biological and clinical determinant in colorectal cancer: progression and future direction
title_full_unstemmed N(6)-methyladenosine as a biological and clinical determinant in colorectal cancer: progression and future direction
title_short N(6)-methyladenosine as a biological and clinical determinant in colorectal cancer: progression and future direction
title_sort n(6)-methyladenosine as a biological and clinical determinant in colorectal cancer: progression and future direction
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7806471/
https://www.ncbi.nlm.nih.gov/pubmed/33456561
http://dx.doi.org/10.7150/thno.52366
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