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Impaired G2/M cell cycle arrest induces apoptosis in pyruvate carboxylase knockdown MDA-MB-231 cells

BACKGROUND: Previous studies showed that suppression of pyruvate carboxylase (PC) expression in highly invasive breast cancer cell line, MDA-MB-231 inhibits cell growth as a consequence of the impaired cellular biosynthesis. However, the precise cellular mechanism underlying this growth restriction...

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Detalles Bibliográficos
Autores principales:	Rattanapornsompong, Khanti, Khattiya, Janya, Phannasil, Phatchariya, Phaonakrop, Narumon, Roytrakul, Sittiruk, Jitrapakdee, Sarawut, Akekawatchai, Chareeporn
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2021
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7806519/ https://www.ncbi.nlm.nih.gov/pubmed/33490650 http://dx.doi.org/10.1016/j.bbrep.2020.100903

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