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Development and implementation of SafeMedWaste, a chemical denaturant for non-hazardous disposal of controlled medications

Substance use disorders are a significant public health issue. Options to dispose of controlled medications are limited, increasing the risk of diversion. Providing an alternative for disposal, a chemical denaturant, SafeMedWaste, was designed to destroy controlled substances irreversibly and safely...

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Autores principales: Leishman, Emma, Wang, Yizhong, Channu, Reddy, Boyst, Evan, Hartmann, Marshall, Stas, Justin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7806595/
https://www.ncbi.nlm.nih.gov/pubmed/33441864
http://dx.doi.org/10.1038/s41598-020-80388-w
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author Leishman, Emma
Wang, Yizhong
Channu, Reddy
Boyst, Evan
Hartmann, Marshall
Stas, Justin
author_facet Leishman, Emma
Wang, Yizhong
Channu, Reddy
Boyst, Evan
Hartmann, Marshall
Stas, Justin
author_sort Leishman, Emma
collection PubMed
description Substance use disorders are a significant public health issue. Options to dispose of controlled medications are limited, increasing the risk of diversion. Providing an alternative for disposal, a chemical denaturant, SafeMedWaste, was designed to destroy controlled substances irreversibly and safely be placed in non-hazardous landfills. Via HPLC–MS, four formulations of SafeMedWaste were tested with 34 different liquid controlled medications from DEA schedules I–V. Beta testing assessed the efficacy of SafeMedWaste in a clinical setting and on waste generated in a manufacturing setting. Furthermore, a formulation of SafeMedWaste was tested on solid controlled medications. All 34 of the liquid medications tested (e.g., amphetamine, diazepam, fentanyl, ketamine) were fully destroyed in SafeMedWaste within 2–24 h. Analysis of a beta test sample of SafeMedWaste containing fentanyl, midazolam, and morphine waste collected in a hospital showed full denaturation of these drugs in 24 h. Variants of SafeMedWaste were optimized to denature six different controlled substance waste samples from a manufacturing facility. In contrast to side-by-side studies with a charcoal disposal system using the same drugs, SafeMedWaste fully inactivated and destroyed the controlled substances in the waste streams. Another formulation of SafeMedWaste was tested on solid medications, which were fully denatured in 48–72 h. In conclusion, SafeMedWaste irreversibly denatures controlled medications that present a problem in our society.
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spelling pubmed-78065952021-01-14 Development and implementation of SafeMedWaste, a chemical denaturant for non-hazardous disposal of controlled medications Leishman, Emma Wang, Yizhong Channu, Reddy Boyst, Evan Hartmann, Marshall Stas, Justin Sci Rep Article Substance use disorders are a significant public health issue. Options to dispose of controlled medications are limited, increasing the risk of diversion. Providing an alternative for disposal, a chemical denaturant, SafeMedWaste, was designed to destroy controlled substances irreversibly and safely be placed in non-hazardous landfills. Via HPLC–MS, four formulations of SafeMedWaste were tested with 34 different liquid controlled medications from DEA schedules I–V. Beta testing assessed the efficacy of SafeMedWaste in a clinical setting and on waste generated in a manufacturing setting. Furthermore, a formulation of SafeMedWaste was tested on solid controlled medications. All 34 of the liquid medications tested (e.g., amphetamine, diazepam, fentanyl, ketamine) were fully destroyed in SafeMedWaste within 2–24 h. Analysis of a beta test sample of SafeMedWaste containing fentanyl, midazolam, and morphine waste collected in a hospital showed full denaturation of these drugs in 24 h. Variants of SafeMedWaste were optimized to denature six different controlled substance waste samples from a manufacturing facility. In contrast to side-by-side studies with a charcoal disposal system using the same drugs, SafeMedWaste fully inactivated and destroyed the controlled substances in the waste streams. Another formulation of SafeMedWaste was tested on solid medications, which were fully denatured in 48–72 h. In conclusion, SafeMedWaste irreversibly denatures controlled medications that present a problem in our society. Nature Publishing Group UK 2021-01-13 /pmc/articles/PMC7806595/ /pubmed/33441864 http://dx.doi.org/10.1038/s41598-020-80388-w Text en © The Author(s) 2021 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Article
Leishman, Emma
Wang, Yizhong
Channu, Reddy
Boyst, Evan
Hartmann, Marshall
Stas, Justin
Development and implementation of SafeMedWaste, a chemical denaturant for non-hazardous disposal of controlled medications
title Development and implementation of SafeMedWaste, a chemical denaturant for non-hazardous disposal of controlled medications
title_full Development and implementation of SafeMedWaste, a chemical denaturant for non-hazardous disposal of controlled medications
title_fullStr Development and implementation of SafeMedWaste, a chemical denaturant for non-hazardous disposal of controlled medications
title_full_unstemmed Development and implementation of SafeMedWaste, a chemical denaturant for non-hazardous disposal of controlled medications
title_short Development and implementation of SafeMedWaste, a chemical denaturant for non-hazardous disposal of controlled medications
title_sort development and implementation of safemedwaste, a chemical denaturant for non-hazardous disposal of controlled medications
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7806595/
https://www.ncbi.nlm.nih.gov/pubmed/33441864
http://dx.doi.org/10.1038/s41598-020-80388-w
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