Cargando…

The association between olfactory dysfunction and cardiovascular disease and its risk factors in middle-aged and older adults

While previous studies have reported olfactory dysfunction (OD) in relation to cardiovascular disease (CVD), few population-based studies have investigated whether such associations differ by sex. The purpose of this study was to identify the association between CVD and its risk factors with OD, and...

Descripción completa

Detalles Bibliográficos
Autores principales: Roh, Daeyoung, Lee, Dong-Hee, Kim, Soo Whan, Kim, Sung Won, Kim, Byung-Guk, Kim, Do Hyun, Shin, Ji-Hyeon
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7806612/
https://www.ncbi.nlm.nih.gov/pubmed/33441955
http://dx.doi.org/10.1038/s41598-020-80943-5
_version_ 1783636561740431360
author Roh, Daeyoung
Lee, Dong-Hee
Kim, Soo Whan
Kim, Sung Won
Kim, Byung-Guk
Kim, Do Hyun
Shin, Ji-Hyeon
author_facet Roh, Daeyoung
Lee, Dong-Hee
Kim, Soo Whan
Kim, Sung Won
Kim, Byung-Guk
Kim, Do Hyun
Shin, Ji-Hyeon
author_sort Roh, Daeyoung
collection PubMed
description While previous studies have reported olfactory dysfunction (OD) in relation to cardiovascular disease (CVD), few population-based studies have investigated whether such associations differ by sex. The purpose of this study was to identify the association between CVD and its risk factors with OD, and the sex-associated differences within the general population. We examined 20,016 adults aged 40 and older from the Korean National Health and Nutrition Examination Survey. All subjects reported on their history of OD. CVD and its risk factors included coronary artery disease (CAD), stroke, hypertension, diabetes, obesity, abdominal obesity, and hypertriglyceridemia; logistic regression was used to analyse their associations with OD, and additive interaction was used to analyse the interaction between risk factors and sex. In males, CAD was more likely to be associated with OD (odds ratio [OR] 1.81, 95% confidence interval [CI] 1.05–3.14), whereas abdominal obesity was associated with OD in females (OR 1.39, 95% CI 1.06–1.84).Additive interaction were observed between abdominal obesity and female sex with a relative excess risk of interaction of 0.45 (95% CI 0.26–0.63). Our findings suggest the relationship between OD and CVD and its risk factors and sex-associated differences among middle-aged and older adults.
format Online
Article
Text
id pubmed-7806612
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher Nature Publishing Group UK
record_format MEDLINE/PubMed
spelling pubmed-78066122021-01-14 The association between olfactory dysfunction and cardiovascular disease and its risk factors in middle-aged and older adults Roh, Daeyoung Lee, Dong-Hee Kim, Soo Whan Kim, Sung Won Kim, Byung-Guk Kim, Do Hyun Shin, Ji-Hyeon Sci Rep Article While previous studies have reported olfactory dysfunction (OD) in relation to cardiovascular disease (CVD), few population-based studies have investigated whether such associations differ by sex. The purpose of this study was to identify the association between CVD and its risk factors with OD, and the sex-associated differences within the general population. We examined 20,016 adults aged 40 and older from the Korean National Health and Nutrition Examination Survey. All subjects reported on their history of OD. CVD and its risk factors included coronary artery disease (CAD), stroke, hypertension, diabetes, obesity, abdominal obesity, and hypertriglyceridemia; logistic regression was used to analyse their associations with OD, and additive interaction was used to analyse the interaction between risk factors and sex. In males, CAD was more likely to be associated with OD (odds ratio [OR] 1.81, 95% confidence interval [CI] 1.05–3.14), whereas abdominal obesity was associated with OD in females (OR 1.39, 95% CI 1.06–1.84).Additive interaction were observed between abdominal obesity and female sex with a relative excess risk of interaction of 0.45 (95% CI 0.26–0.63). Our findings suggest the relationship between OD and CVD and its risk factors and sex-associated differences among middle-aged and older adults. Nature Publishing Group UK 2021-01-13 /pmc/articles/PMC7806612/ /pubmed/33441955 http://dx.doi.org/10.1038/s41598-020-80943-5 Text en © The Author(s) 2021 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Article
Roh, Daeyoung
Lee, Dong-Hee
Kim, Soo Whan
Kim, Sung Won
Kim, Byung-Guk
Kim, Do Hyun
Shin, Ji-Hyeon
The association between olfactory dysfunction and cardiovascular disease and its risk factors in middle-aged and older adults
title The association between olfactory dysfunction and cardiovascular disease and its risk factors in middle-aged and older adults
title_full The association between olfactory dysfunction and cardiovascular disease and its risk factors in middle-aged and older adults
title_fullStr The association between olfactory dysfunction and cardiovascular disease and its risk factors in middle-aged and older adults
title_full_unstemmed The association between olfactory dysfunction and cardiovascular disease and its risk factors in middle-aged and older adults
title_short The association between olfactory dysfunction and cardiovascular disease and its risk factors in middle-aged and older adults
title_sort association between olfactory dysfunction and cardiovascular disease and its risk factors in middle-aged and older adults
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7806612/
https://www.ncbi.nlm.nih.gov/pubmed/33441955
http://dx.doi.org/10.1038/s41598-020-80943-5
work_keys_str_mv AT rohdaeyoung theassociationbetweenolfactorydysfunctionandcardiovasculardiseaseanditsriskfactorsinmiddleagedandolderadults
AT leedonghee theassociationbetweenolfactorydysfunctionandcardiovasculardiseaseanditsriskfactorsinmiddleagedandolderadults
AT kimsoowhan theassociationbetweenolfactorydysfunctionandcardiovasculardiseaseanditsriskfactorsinmiddleagedandolderadults
AT kimsungwon theassociationbetweenolfactorydysfunctionandcardiovasculardiseaseanditsriskfactorsinmiddleagedandolderadults
AT kimbyungguk theassociationbetweenolfactorydysfunctionandcardiovasculardiseaseanditsriskfactorsinmiddleagedandolderadults
AT kimdohyun theassociationbetweenolfactorydysfunctionandcardiovasculardiseaseanditsriskfactorsinmiddleagedandolderadults
AT shinjihyeon theassociationbetweenolfactorydysfunctionandcardiovasculardiseaseanditsriskfactorsinmiddleagedandolderadults
AT rohdaeyoung associationbetweenolfactorydysfunctionandcardiovasculardiseaseanditsriskfactorsinmiddleagedandolderadults
AT leedonghee associationbetweenolfactorydysfunctionandcardiovasculardiseaseanditsriskfactorsinmiddleagedandolderadults
AT kimsoowhan associationbetweenolfactorydysfunctionandcardiovasculardiseaseanditsriskfactorsinmiddleagedandolderadults
AT kimsungwon associationbetweenolfactorydysfunctionandcardiovasculardiseaseanditsriskfactorsinmiddleagedandolderadults
AT kimbyungguk associationbetweenolfactorydysfunctionandcardiovasculardiseaseanditsriskfactorsinmiddleagedandolderadults
AT kimdohyun associationbetweenolfactorydysfunctionandcardiovasculardiseaseanditsriskfactorsinmiddleagedandolderadults
AT shinjihyeon associationbetweenolfactorydysfunctionandcardiovasculardiseaseanditsriskfactorsinmiddleagedandolderadults