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Sphingolipids and physical function in the Atherosclerosis Risk in Communities (ARIC) study
Long-chain sphingomyelins (SMs) may play an important role in the stability of myelin sheath underlying physical function. The objective of this study was to examine the cross-sectional and longitudinal associations of long-chain SMs [SM (41:1), SM (41:2), SM (43:1)] and ceramides [Cer (41:1) and Ce...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Nature Publishing Group UK
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7806657/ https://www.ncbi.nlm.nih.gov/pubmed/33441925 http://dx.doi.org/10.1038/s41598-020-80929-3 |
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author | Li, Danni Alam, Aniqa B. Yu, Fang Kucharska-Newton, Anna Windham, B. Gwen Alonso, Alvaro |
author_facet | Li, Danni Alam, Aniqa B. Yu, Fang Kucharska-Newton, Anna Windham, B. Gwen Alonso, Alvaro |
author_sort | Li, Danni |
collection | PubMed |
description | Long-chain sphingomyelins (SMs) may play an important role in the stability of myelin sheath underlying physical function. The objective of this study was to examine the cross-sectional and longitudinal associations of long-chain SMs [SM (41:1), SM (41:2), SM (43:1)] and ceramides [Cer (41:1) and Cer (43:1)] with physical function in the Atherosclerosis Risk in Communities (ARIC) study. Plasma concentrations of SM (41:1), SM (41:2), SM (43:1), Cer (41:1) and Cer (43:1) were measured in 389 ARIC participants in 2011–13. Physical function was assessed by grip strength, Short Physical Performance Battery (SPPB), 4-m walking speed at both 2011–13 and 2016–17, and the modified Rosow-Breslau questionnaire in 2016–2017. Multivariable linear and logistic regression analyses were performed, controlling for demographic and clinical confounders. In cross-sectional analyses, plasma concentrations of SM 41:1 were positively associated with SPPB score (β-coefficients [95% confidence internal]: 0.33 [0.02, 0.63] per 1 standard deviation [SD] increase in log-transformed concentration, p value 0.04), 4-m walking speed (0.042 m/s [0.01, 0.07], p value 0.003), and negatively with self-reported disability (odds ratio = 0.73 [0.65, 0.82], p value < 0.0001). Plasma concentrations of the five metabolites examined were not significantly associated with longitudinal changes in physical function or incidence of poor mobility. In older adults, plasma concentrations of long-chain SM 41:1 were cross-sectionally positively associated with physical function. |
format | Online Article Text |
id | pubmed-7806657 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-78066572021-01-14 Sphingolipids and physical function in the Atherosclerosis Risk in Communities (ARIC) study Li, Danni Alam, Aniqa B. Yu, Fang Kucharska-Newton, Anna Windham, B. Gwen Alonso, Alvaro Sci Rep Article Long-chain sphingomyelins (SMs) may play an important role in the stability of myelin sheath underlying physical function. The objective of this study was to examine the cross-sectional and longitudinal associations of long-chain SMs [SM (41:1), SM (41:2), SM (43:1)] and ceramides [Cer (41:1) and Cer (43:1)] with physical function in the Atherosclerosis Risk in Communities (ARIC) study. Plasma concentrations of SM (41:1), SM (41:2), SM (43:1), Cer (41:1) and Cer (43:1) were measured in 389 ARIC participants in 2011–13. Physical function was assessed by grip strength, Short Physical Performance Battery (SPPB), 4-m walking speed at both 2011–13 and 2016–17, and the modified Rosow-Breslau questionnaire in 2016–2017. Multivariable linear and logistic regression analyses were performed, controlling for demographic and clinical confounders. In cross-sectional analyses, plasma concentrations of SM 41:1 were positively associated with SPPB score (β-coefficients [95% confidence internal]: 0.33 [0.02, 0.63] per 1 standard deviation [SD] increase in log-transformed concentration, p value 0.04), 4-m walking speed (0.042 m/s [0.01, 0.07], p value 0.003), and negatively with self-reported disability (odds ratio = 0.73 [0.65, 0.82], p value < 0.0001). Plasma concentrations of the five metabolites examined were not significantly associated with longitudinal changes in physical function or incidence of poor mobility. In older adults, plasma concentrations of long-chain SM 41:1 were cross-sectionally positively associated with physical function. Nature Publishing Group UK 2021-01-13 /pmc/articles/PMC7806657/ /pubmed/33441925 http://dx.doi.org/10.1038/s41598-020-80929-3 Text en © The Author(s) 2021 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. |
spellingShingle | Article Li, Danni Alam, Aniqa B. Yu, Fang Kucharska-Newton, Anna Windham, B. Gwen Alonso, Alvaro Sphingolipids and physical function in the Atherosclerosis Risk in Communities (ARIC) study |
title | Sphingolipids and physical function in the Atherosclerosis Risk in Communities (ARIC) study |
title_full | Sphingolipids and physical function in the Atherosclerosis Risk in Communities (ARIC) study |
title_fullStr | Sphingolipids and physical function in the Atherosclerosis Risk in Communities (ARIC) study |
title_full_unstemmed | Sphingolipids and physical function in the Atherosclerosis Risk in Communities (ARIC) study |
title_short | Sphingolipids and physical function in the Atherosclerosis Risk in Communities (ARIC) study |
title_sort | sphingolipids and physical function in the atherosclerosis risk in communities (aric) study |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7806657/ https://www.ncbi.nlm.nih.gov/pubmed/33441925 http://dx.doi.org/10.1038/s41598-020-80929-3 |
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