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Age affects procedural paired-associates learning in the grey mouse lemur (Microcebus murinus)
The ability to associate memorized objects with their location in space gradually declines during normal aging and can drastically be affected by neurodegenerative diseases. This study investigates object-location paired-associates learning (PAL) in the grey mouse lemur (Microcebus murinus), a nonhu...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Nature Publishing Group UK
2021
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7806666/ https://www.ncbi.nlm.nih.gov/pubmed/33442034 http://dx.doi.org/10.1038/s41598-021-80960-y |
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author | Schmidtke, Daniel |
author_facet | Schmidtke, Daniel |
author_sort | Schmidtke, Daniel |
collection | PubMed |
description | The ability to associate memorized objects with their location in space gradually declines during normal aging and can drastically be affected by neurodegenerative diseases. This study investigates object-location paired-associates learning (PAL) in the grey mouse lemur (Microcebus murinus), a nonhuman primate model of brain aging. Touchscreen-based testing of 6 young adults (1–5 years) and 6 old adults (> 7 years) in the procedural rodent dPAL-task revealed significant age-related performance decline, evident in group differences in the percentage of correct decision during learning and the number of sessions needed to reach a predefined criterion. Response pattern analyses suggest decreased susceptibility to relative stimulus-position biases in young animals, facilitating PAL. Additional data from a subset of “overtrained” individuals (n = 7) and challenge sessions using a modified protocol (sPAL) further suggest that learning criteria routinely used in animal studies on PAL can underestimate the endpoint at which a stable performance is reached and that more conservative criteria are needed to improve construct validity of the task. To conclude, this is the first report of an age effect on dPAL and corroborates the role of mouse lemurs as valuable natural nonhuman primate models in aging research. |
format | Online Article Text |
id | pubmed-7806666 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-78066662021-01-14 Age affects procedural paired-associates learning in the grey mouse lemur (Microcebus murinus) Schmidtke, Daniel Sci Rep Article The ability to associate memorized objects with their location in space gradually declines during normal aging and can drastically be affected by neurodegenerative diseases. This study investigates object-location paired-associates learning (PAL) in the grey mouse lemur (Microcebus murinus), a nonhuman primate model of brain aging. Touchscreen-based testing of 6 young adults (1–5 years) and 6 old adults (> 7 years) in the procedural rodent dPAL-task revealed significant age-related performance decline, evident in group differences in the percentage of correct decision during learning and the number of sessions needed to reach a predefined criterion. Response pattern analyses suggest decreased susceptibility to relative stimulus-position biases in young animals, facilitating PAL. Additional data from a subset of “overtrained” individuals (n = 7) and challenge sessions using a modified protocol (sPAL) further suggest that learning criteria routinely used in animal studies on PAL can underestimate the endpoint at which a stable performance is reached and that more conservative criteria are needed to improve construct validity of the task. To conclude, this is the first report of an age effect on dPAL and corroborates the role of mouse lemurs as valuable natural nonhuman primate models in aging research. Nature Publishing Group UK 2021-01-13 /pmc/articles/PMC7806666/ /pubmed/33442034 http://dx.doi.org/10.1038/s41598-021-80960-y Text en © The Author(s) 2021 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. |
spellingShingle | Article Schmidtke, Daniel Age affects procedural paired-associates learning in the grey mouse lemur (Microcebus murinus) |
title | Age affects procedural paired-associates learning in the grey mouse lemur (Microcebus murinus) |
title_full | Age affects procedural paired-associates learning in the grey mouse lemur (Microcebus murinus) |
title_fullStr | Age affects procedural paired-associates learning in the grey mouse lemur (Microcebus murinus) |
title_full_unstemmed | Age affects procedural paired-associates learning in the grey mouse lemur (Microcebus murinus) |
title_short | Age affects procedural paired-associates learning in the grey mouse lemur (Microcebus murinus) |
title_sort | age affects procedural paired-associates learning in the grey mouse lemur (microcebus murinus) |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7806666/ https://www.ncbi.nlm.nih.gov/pubmed/33442034 http://dx.doi.org/10.1038/s41598-021-80960-y |
work_keys_str_mv | AT schmidtkedaniel ageaffectsproceduralpairedassociateslearninginthegreymouselemurmicrocebusmurinus |