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Embeddings from deep learning transfer GO annotations beyond homology

Knowing protein function is crucial to advance molecular and medical biology, yet experimental function annotations through the Gene Ontology (GO) exist for fewer than 0.5% of all known proteins. Computational methods bridge this sequence-annotation gap typically through homology-based annotation tr...

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Detalles Bibliográficos
Autores principales: Littmann, Maria, Heinzinger, Michael, Dallago, Christian, Olenyi, Tobias, Rost, Burkhard
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7806674/
https://www.ncbi.nlm.nih.gov/pubmed/33441905
http://dx.doi.org/10.1038/s41598-020-80786-0