Angiotensin II type 1a receptor loss ameliorates chronic tubulointerstitial damage after renal ischemia reperfusion

We investigate whether suppressing the activation of the angiotensin II type 1a receptor (AT1a) can ameliorate severe chronic tubulointerstitial damage (TID) after renal ischemia reperfusion (IR) using AT1a knockout homozygous (AT1a(−/−)) male mice. To induce severe chronic TID after renal IR, unila...

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Detalles Bibliográficos
Autores principales: Fujita, Yoko, Ichikawa, Daisuke, Sugaya, Takeshi, Ohata, Keiichi, Tanabe, Jun, Inoue, Kazuho, Hoshino, Seiko, Togo, Tatsuru, Watanabe, Minoru, Kimura, Kenjiro, Shibagaki, Yugo, Kamijo-Ikemori, Atsuko
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7806698/
https://www.ncbi.nlm.nih.gov/pubmed/33441837
http://dx.doi.org/10.1038/s41598-020-80209-0

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