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Maternal Roux-en-Y gastric bypass surgery reduces lipid deposition and increases UCP1 expression in the brown adipose tissue of male offspring
Maternal obesity induced by cafeteria diet (CAF) predisposes offspring to obesity and metabolic diseases, events that could be avoided by maternal bariatric surgery (BS). Herein we evaluated whether maternal BS is able to modulate brown adipose tissue (BAT) morphology and function in adult male rats...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7806700/ https://www.ncbi.nlm.nih.gov/pubmed/33441773 http://dx.doi.org/10.1038/s41598-020-80104-8 |
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author | Ceglarek, Vanessa Marieli Bertasso, Iala Milene Pietrobon, Carla Bruna Scomazzon, Sofia Pizzato Leite, Nayara Carvalho Bonfleur, Maria Lúcia Araújo, Allan Cezar Faria Balbo, Sandra Lucinei Grassiolli, Sabrina |
author_facet | Ceglarek, Vanessa Marieli Bertasso, Iala Milene Pietrobon, Carla Bruna Scomazzon, Sofia Pizzato Leite, Nayara Carvalho Bonfleur, Maria Lúcia Araújo, Allan Cezar Faria Balbo, Sandra Lucinei Grassiolli, Sabrina |
author_sort | Ceglarek, Vanessa Marieli |
collection | PubMed |
description | Maternal obesity induced by cafeteria diet (CAF) predisposes offspring to obesity and metabolic diseases, events that could be avoided by maternal bariatric surgery (BS). Herein we evaluated whether maternal BS is able to modulate brown adipose tissue (BAT) morphology and function in adult male rats born from obese female rats submitted to Roux-en-Y gastric bypass (RYGB). For this, adult male rat offspring were obtained from female rats that consumed standard diet (CTL), or CAF diet, and were submitted to simulated operation or RYGB. Analysis of offspring showed that, at 120 days of life, the maternal CAF diet induced adiposity and decreased the expression of mitochondrial Complex I (CI) and Complex III (CIII) in the BAT, resulting in higher accumulation of lipids than in BAT from offspring of CTL dams. Moreover, maternal RYGB increased UCP1 expression and prevented excessive deposition of lipids in the BAT of adult male offspring rats. However, maternal RYGB failed to reverse the effects of maternal diet on CI and CIII expression. Thus, maternal CAF promotes higher lipid deposition in the BAT of offspring, contributing to elevated adiposity. Maternal RYGB prevented obesity in offspring, probably by increasing the expression of UCP1. |
format | Online Article Text |
id | pubmed-7806700 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-78067002021-01-14 Maternal Roux-en-Y gastric bypass surgery reduces lipid deposition and increases UCP1 expression in the brown adipose tissue of male offspring Ceglarek, Vanessa Marieli Bertasso, Iala Milene Pietrobon, Carla Bruna Scomazzon, Sofia Pizzato Leite, Nayara Carvalho Bonfleur, Maria Lúcia Araújo, Allan Cezar Faria Balbo, Sandra Lucinei Grassiolli, Sabrina Sci Rep Article Maternal obesity induced by cafeteria diet (CAF) predisposes offspring to obesity and metabolic diseases, events that could be avoided by maternal bariatric surgery (BS). Herein we evaluated whether maternal BS is able to modulate brown adipose tissue (BAT) morphology and function in adult male rats born from obese female rats submitted to Roux-en-Y gastric bypass (RYGB). For this, adult male rat offspring were obtained from female rats that consumed standard diet (CTL), or CAF diet, and were submitted to simulated operation or RYGB. Analysis of offspring showed that, at 120 days of life, the maternal CAF diet induced adiposity and decreased the expression of mitochondrial Complex I (CI) and Complex III (CIII) in the BAT, resulting in higher accumulation of lipids than in BAT from offspring of CTL dams. Moreover, maternal RYGB increased UCP1 expression and prevented excessive deposition of lipids in the BAT of adult male offspring rats. However, maternal RYGB failed to reverse the effects of maternal diet on CI and CIII expression. Thus, maternal CAF promotes higher lipid deposition in the BAT of offspring, contributing to elevated adiposity. Maternal RYGB prevented obesity in offspring, probably by increasing the expression of UCP1. Nature Publishing Group UK 2021-01-13 /pmc/articles/PMC7806700/ /pubmed/33441773 http://dx.doi.org/10.1038/s41598-020-80104-8 Text en © The Author(s) 2021 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. |
spellingShingle | Article Ceglarek, Vanessa Marieli Bertasso, Iala Milene Pietrobon, Carla Bruna Scomazzon, Sofia Pizzato Leite, Nayara Carvalho Bonfleur, Maria Lúcia Araújo, Allan Cezar Faria Balbo, Sandra Lucinei Grassiolli, Sabrina Maternal Roux-en-Y gastric bypass surgery reduces lipid deposition and increases UCP1 expression in the brown adipose tissue of male offspring |
title | Maternal Roux-en-Y gastric bypass surgery reduces lipid deposition and increases UCP1 expression in the brown adipose tissue of male offspring |
title_full | Maternal Roux-en-Y gastric bypass surgery reduces lipid deposition and increases UCP1 expression in the brown adipose tissue of male offspring |
title_fullStr | Maternal Roux-en-Y gastric bypass surgery reduces lipid deposition and increases UCP1 expression in the brown adipose tissue of male offspring |
title_full_unstemmed | Maternal Roux-en-Y gastric bypass surgery reduces lipid deposition and increases UCP1 expression in the brown adipose tissue of male offspring |
title_short | Maternal Roux-en-Y gastric bypass surgery reduces lipid deposition and increases UCP1 expression in the brown adipose tissue of male offspring |
title_sort | maternal roux-en-y gastric bypass surgery reduces lipid deposition and increases ucp1 expression in the brown adipose tissue of male offspring |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7806700/ https://www.ncbi.nlm.nih.gov/pubmed/33441773 http://dx.doi.org/10.1038/s41598-020-80104-8 |
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