Discovery of small molecules targeting the tandem tudor domain of the epigenetic factor UHRF1 using fragment-based ligand discovery

Despite the established roles of the epigenetic factor UHRF1 in oncogenesis, no UHRF1-targeting therapeutics have been reported to date. In this study, we use fragment-based ligand discovery to identify novel scaffolds for targeting the isolated UHRF1 tandem Tudor domain (TTD), which recognizes the...

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Detalles Bibliográficos
Autores principales: Chang, Lyra, Campbell, James, Raji, Idris O., Guduru, Shiva K. R., Kandel, Prasanna, Nguyen, Michelle, Liu, Steven, Tran, Kevin, Venugopal, Navneet K., Taylor, Bethany C., Holt, Matthew V., Young, Nicolas L., Samuel, Errol L. G., Jain, Prashi, Santini, Conrad, Sankaran, Banumathi, MacKenzie, Kevin R., Young, Damian W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7806715/
https://www.ncbi.nlm.nih.gov/pubmed/33441849
http://dx.doi.org/10.1038/s41598-020-80588-4

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