Discovery of a highly potent novel rifampicin analog by preparing a hybrid of the precursors of the antibiotic drugs rifampicin and clofazimine

Tuberculosis (TB) is an infectious disease caused by the bacillus Mycobacterium tuberculosis (Mtb). The present work reports the design and synthesis of a hybrid of the precursors of rifampicin and clofazimine, which led to the discovery of a novel Rifaphenazine (RPZ) molecule with potent anti-TB ac...

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Detalles Bibliográficos
Autores principales: Saravanan, Pasupathy, Dusthackeer, V. N. Azger, Rajmani, R. S., Mahizhaveni, B., Nirmal, Christy R., Rajadas, Sam Ebenezer, Bhardwaj, Neerupma, Ponnuraja, C., Bhaskar, Adhin, Hemanthkumar, A. K., Ramachandran, Geetha, Tripathy, Srikanth P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7806721/
https://www.ncbi.nlm.nih.gov/pubmed/33441878
http://dx.doi.org/10.1038/s41598-020-80439-2

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