Sustained, local delivery of the PARP inhibitor talazoparib prevents the development of mammary gland hyperplasia in Brca1-deficient mice

Mutations in BRCA genes are the leading cause of hereditary breast cancer. Current options to prevent cancer in these high-risk patients, such as anti-estrogen drugs and radical mastectomy, are limited by lack of efficacy, undesirable toxicities, or physical and emotional challenges. We have previou...

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Detalles Bibliográficos
Autores principales: Zhang, Di, Singh, Bijay, Moerland, Jessica, Mitchell, Owen, Lockwood, Lizbeth, Carapellucci, Sarah, Sridhar, Srinivas, Liby, Karen T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7806744/
https://www.ncbi.nlm.nih.gov/pubmed/33441637
http://dx.doi.org/10.1038/s41598-020-79663-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7806744/
https://www.ncbi.nlm.nih.gov/pubmed/33441637
http://dx.doi.org/10.1038/s41598-020-79663-7

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