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d,l-Methadone causes leukemic cell apoptosis via an OPRM1-triggered increase in IP3R-mediated ER Ca(2+) release and decrease in Ca(2+) efflux, elevating [Ca(2+)](i)

The search continues for improved therapy for acute lymphoblastic leukemia (aLL), the most common malignancy in children. Recently, d,l-methadone was put forth as sensitizer for aLL chemotherapy. However, the specific target of d,l-methadone in leukemic cells and the mechanism by which it induces le...

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Detalles Bibliográficos
Autores principales:	Lee, JungKwon, Rosales, Jesusa L., Byun, Hee-Guk, Lee, Ki-Young
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7806773/ https://www.ncbi.nlm.nih.gov/pubmed/33441856 http://dx.doi.org/10.1038/s41598-020-80520-w

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