Tethering-induced destabilization and ATP-binding for tandem RRM domains of ALS-causing TDP-43 and hnRNPA1

TDP-43 and hnRNPA1 contain tandemly-tethered RNA-recognition-motif (RRM) domains, which not only functionally bind an array of nucleic acids, but also participate in aggregation/fibrillation, a pathological hallmark of various human diseases including amyotrophic lateral sclerosis (ALS), frontotempo...

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Detalles Bibliográficos
Autores principales: Dang, Mei, Li, Yifan, Song, Jianxing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7806782/
https://www.ncbi.nlm.nih.gov/pubmed/33441818
http://dx.doi.org/10.1038/s41598-020-80524-6

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7806782/
https://www.ncbi.nlm.nih.gov/pubmed/33441818
http://dx.doi.org/10.1038/s41598-020-80524-6

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